Cocrystallization via planetary milling: Enhancing throughput of solid-state screening methods
Cocrystallization via planetary milling: Enhancing throughput of solid-state screening methods
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DOI：
10.1016/j.ijpharm.2011.03.037
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发表时间：
2011-06-15
影响因子：
5.8
通讯作者：
Igo, David
中科院分区：
文献类型：
--
作者：
Bysouth, Stephen R.;Bis, Joanna A.;Igo, David
一种新型的改性行星磨机，具有并行处理48个样品的能力，通过研磨药物共晶的快速筛选的应用程序被证明为卡马西平/糖精，咖啡因/草酸，咖啡因/马来酸共晶。研磨直接在标准玻璃小瓶中进行，因此不需要容器去污或发生样品损失。此外，可以采用连续的样品处理，而不需要额外的材料，使该系统适用于筛选有限的可用性的化合物。还讨论了该系统在自动化筛选工作流程中的分配，研磨和高通量分析。(C)2011 Elsevier B. V.保留所有权利。
The application of a novel modified planetary mill, with the capacity to process 48 samples in parallel, to the rapid screening of pharmaceutical cocrystals via grinding is demonstrated for carbamazepine/saccharin, caffeine/oxalic acid, and caffeine/maleic acid cocrystals. Milling is performed directly in standard glass vials therefore no vessel decontamination is needed or sample loss occurs. Furthermore, successive sample processing can be employed without the need for additional material, making the system suitable for screening compounds of limited availability. Use of the system in an automated screening workflow of dispensing, milling, and analysis with high-throughput is also discussed. (C) 2011 Elsevier B.V. All rights reserved.