Imaging with prostate-specific membrane antigen (PSMA) in prostate cancer
Imaging with prostate-specific membrane antigen (PSMA) in prostate cancer
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DOI：
10.1038/sj.pcan.4500390
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发表时间：
2000-01-01
影响因子：
4.8
通讯作者：
Britton, KE
中科院分区：
文献类型：
--
作者：
Feneley, MR;Jan, H;Britton, KE
使用放射性标记的前列腺特异性膜抗原（PSMA）的抗体的放射免疫闪烁成像作为基于功能特征的组织特异性成像的手段，并补充传统的分期调查，具有越来越多的应用。在男性前列腺癌的临床应用正在完善，这项研究报告的结果与这项技术在我们的实践。用In-ill CYT 356对49例前列腺增生症患者进行了前列腺免疫闪烁扫描。前列腺癌，在10分钟、24和48小时获得二维和三维连续图像。在49名男性中，36名患有临床局限性癌症，10名在根治性放疗或根治性乳腺切除术后复发，3名在初次内分泌治疗后PSA升高。扫描结果进行了讨论的背景下，临床管理。在36名临床上患有局部癌症的男性中，7名在区域和远处淋巴结中的摄取增加。在这7例患者中，3例接受了激素治疗，2例接受了根治性乳房切除术，2例接受了根治性放疗。在10例原发肿瘤根治性治疗后复发的患者中，扫描显示4例仅局部复发，6例有区域或远处转移。3例接受激素治疗的患者扫描显示PSA升高，其中1例区域淋巴结阳性，2例远处软组织和骨转移。总之，前列腺放射免疫显像扫描突出前列腺癌累及的组织，包括前列腺、淋巴结、软组织和骨转移以及盆腔复发。结果可能有助于个体患者的临床管理，尽管在考虑替代治疗时，组织学确认可能是适当的。
Radioimmunoscintigraphy using a radio-labelled antibody to prostate-specific membrane antigen (PSMA) has growing applications as a means of tissue-specific imaging based on functional characteristics and complements traditional staging investigations. Clinical applications in men with carcinoma of the prostate are being refined, and this study reports outcomes with this technique in our practice. Prostatic immunoscintigraphy scans were performed with In-ill CYT 356 in 49 men with. carcinoma of the prostate, obtaining sequential images in two and three dimensions at 10 min, 24 and 48 h. Of the 49 men, 36 had clinically localized cancer, 10 had recurrent disease after radical radiotherapy or radical prostatectomy and three had rising PSA after primary endocrine treatment. Scan findings are discussed in the context of clinical management. Of the 36 men with clinically localized cancer, seven had increased uptake in regional and distant lymph nodes. Of these seven, three were treated with hormone manipulation, two by radical prostatectomy and two by radical radiotherapy. Among 10 patients who had recurrence after radical treatment of the primary tumour, scans showed local recurrence alone in four, and six had regional or distant metastases. Three patients treated with primary hormone manipulation had scans for rising PSA, and of these one had a positive regional node and two had distant soft tissue and bone metastases. In conclusion, prostatic radio-immunoscintigraphy scans highlight tissues involved by prostate cancer, including the prostate, lymph nodes, soft tissues and bone metastases as well as pelvic recurrence. Results may contribute to the clinical management of individual patients, although histological confirmation may be appropriate when considering alternative treatment.