Hyperhydroxylation:: A new strategy for neuronal targeting by venomous marine molluscs
Hyperhydroxylation:: A new strategy for neuronal targeting by venomous marine molluscs
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DOI：
10.1007/978-3-540-30880-5_4
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Mari, F.
中科院分区：
文献类型：
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作者：
Franco, A.;Pisarewicz, K.;Mari, F.
有毒的海洋软体动物属于芋螺属（锥螺）利用一种独特的神经化学策略来捕获猎物。它们的毒液由高度修饰的肽（锥肽）的复杂混合物组成，这些肽与广泛的神经元靶点相互作用。在这一章中，我们描述了一套修改的基础上的多肽链的羟基化，是定义内的神经化学策略锥螺捕捉猎物。特别地，我们提出了一种差异羟基化策略，其影响一组新的α-芋螺毒素、mini-M芋螺毒素、芋螺素和γ-羟基芋螺素的神经元靶向。在这些芋螺肽家族中已经观察到差异羟基化、优先羟基化和超羟基化，作为增强芋螺用于神经元靶向和猎物捕获的毒液库的手段。
Venomous marine molluscs belonging to the genus Conus (cone snails) utilize a unique neurochemical strategy to capture their prey. Their venom is composed of a complex mixture of highly modified peptides (conopeptides) that interact with a wide range of neuronal targets. In this chapter, we describe a set of modifications based upon the hydroxylation of polypeptidic chains that are defining within the neurochemical strategy used by cone snails to capture their prey. In particular, we present a differential hydroxylation strategy that affects the neuronal targeting of a new set of α-conotoxins, mini-M conotoxins, conophans, and γ-hydroxyconophans. Differential hydroxylation, preferential hydroxylation and hyperhydroxylation have been observed in these conopeptide families as a means of augmenting the venom arsenal used by cone snails for neuronal targeting and prey capture.