Three-dimensional Poisson-Nernst-Planck theory studies:: Influence of membrane electrostatics on gramicidin A channel conductance
Three-dimensional Poisson-Nernst-Planck theory studies:: Influence of membrane electrostatics on gramicidin A channel conductance
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DOI：
10.1016/s0006-3495(00)76275-8
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发表时间：
2000-07-01
影响因子：
3.4
通讯作者：
Kurnikova, MG
中科院分区：
文献类型：
--
作者：
Cárdenas, AE;Coalson, RD;Kurnikova, MG
一种最近引入的用于求解三维泊松 - 能斯特 - 普朗克方程的实空间晶格方法被用于计算离子通过短杆菌肽A离子通道的电流 - 电压关系，该离子通道嵌入具有表面偶极子和/或表面电荷特征的膜中。在此呈现的与各种实验结果的比较在很大程度上是成功的。文中讨论了该方法的优点和缺点。
A recently introduced real-space lattice methodology for solving the three-dimensional Poisson-Nernst-Planck equations is used to compute current-voltage relations for ion permeation through the gramicidin A ion channel embedded in membranes characterized by surface dipoles and/or surface charge. Comparisons to a variety of experimental results, presented herein, have proven largely successful. Strengths and weaknesses of the method are discussed.