Overweight is Associated with Lower Resting State Functional Connectivity in Females After Eliminating Genetic Effects: A Twin Study
Overweight is Associated with Lower Resting State Functional Connectivity in Females After Eliminating Genetic Effects: A Twin Study
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DOI：
10.1002/hbm.23715
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发表时间：
2017-10-01
影响因子：
4.8
通讯作者：
IJzerman, Richard G.
中科院分区：
文献类型：
--
作者：
Doornweerd, Stieneke;van Duinkerken, Eelco;IJzerman, Richard G.
肥胖与与奖赏和动机有关的静息状态大脑网络的功能连接改变有关。目前尚不清楚这些关联在多大程度上反映了遗传混淆，以及肥胖相关的连接性变化是否与饮食摄入量的差异有关。在这项研究中，16对女性单卵双生子(年龄48.8+/-69.8岁)在隔夜禁食后进行了静息状态的功能磁共振成像，平均BMI不一致性为3.96+/-62.1 kg/m(2)(范围0.7-8.2)。用独立成分分析检测突起、基底节、默认模式和前扣带回-眶前叶皮质网络的功能连接性。饮食摄入量通过3天24小时回忆进行评估。结果显示，在基底节网络内，体重较重与较瘦的同卵双胞胎降低了双侧壳核的功能连接强度(P<；0.05，经四次校正)。在检查的其他网络中，连接性没有差异。总体而言，左侧壳核功能连接强度降低与总脂肪摄入量增加相关(P<；0.01)。结论是，在消除遗传效应后，超重与基底神经节网络中双侧壳核的静息状态功能连接性降低有关。较低的壳核连通性和较高的脂肪摄入量之间的联系表明，壳核在食欲机制中扮演着重要的角色。我们研究的横截面性质不能区分原因和结果，但这一发现与较低的壳核连接性对增加BMI和相关的较高脂肪摄入量的影响是一致的。(C)2017威利期刊公司。
Obesity is related to altered functional connectivity of resting state brain networks that are involved in reward and motivation. It is unknown to what extent these associations reflect genetic confounding and whether the obesity-related connectivity changes are associated with differences in dietary intake. In this study, resting state functional MRI was performed after an overnight fast in 16 female monozygotic twin pairs (aged 48.8 +/- 69.8 years) with a mean BMI discordance of 3.96 +/- 62.1 kg/m(2) (range 0.7-8.2). Functional connectivity of the salience, basal ganglia, default mode and anterior cingulate- orbitofrontal cortex networks was examined by independent component analysis. Dietary intake was assessed using 3-day 24-hour recalls. Results revealed that within the basal ganglia network, heavier versus leaner co-twins have decreased functional connectivity strength in bilateral putamen (P< 0.05, FWE-corrected). There were no differences in connectivity in the other networks examined. In the overall group, lower functional connectivity strength in the left putamen was correlated with higher intake of total fat (P< 0.01). It was concluded that, after eliminating genetic effects, overweight is associated with lower resting state functional connectivity in bilateral putamen in the basal ganglia network. The association between lower putamen connectivity and higher fat intake suggests an important role of the putamen in appetitive mechanisms. The cross-sectional nature of our study cannot discriminate cause and consequence, but the findings are compatible with an effect of lower putamen connectivity on increased BMI and associated higher fat intake. (C) 2017 Wiley Periodicals, Inc.