Association between N-terminal pro BNP and day-to-day blood pressure and heart rate variability in a general population: The Ohasama Study.
Association between N-terminal pro BNP and day-to-day blood pressure and heart rate variability in a general population: The Ohasama Study.
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一般人群中 N 末端 BNP 前体与日常血压和心率变异性之间的关联：Ohasama 研究。
DOI：
10.1097/hjh.0000000000000570
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发表时间：
2015
影响因子：
4.9
通讯作者：
Ohkubo T.
中科院分区：
文献类型：
--
作者：
Satoh M;Hosaka M;Asayama K;Kikuya M;Inoue R;Metoki H;Tsubota-Utsugi M;Hara A;Hirose T;Obara T;Totsune K;Hoshi H;Mano N;Node K;Imai Y;Ohkubo T.
背景：除了血压（BP）或心率（HR）的每日变异性外，N末端B型利钠肽前体（NT-proBNP）已被报道为心血管疾病的预测因子。在这里，我们在一项横断面研究中检验了这样一个假设，即每日血压或心率变异性（计算为家庭血压或心率的个体内标准差（SD））与NT-proBNP升高相关。（平均年龄，61.9岁;女性，70.5%）来自无心脏病史的一般日本人群，86结果：NT-proBNP ≥ 125 pg/ml者占13.0%。0001）和家庭HR的SD中（OR，1.44; P= 0.008）与NT-proBNP患病率显著相关，在调整可能的混杂因素（包括家庭SBP和HR）后，NT-proBNP患病率至少为125 pg/ml。家庭SBP SD较高的组（≥ 8.0 mmHg）和HR（≥ 5.0 bpm）NT-proBNP患病率的最大OR至少为125 pg/ml（OR，4.80; P= 0.007，与家庭SBP和HR的SD较低的参考组相比）。这些结果表明，BP和HR的日常变化可能与靶器官损伤或并发症相关，这可能导致NT-proBNP水平升高。NT-proBNP水平升高可能与BP或HR的日间变异性的预后意义有关。
Background:In addition to day-to-day variability in blood pressure (BP) or heart rate (HR), N-terminal pro B-type natriuretic peptide (NT-proBNP) has been reported to be a predictor of cardiovascular disease. Here, we tested the hypothesis that day-to-day BP or HR variability calculated as the intraindividual standard deviation (SD) of home BP or HR is associated with elevated NT-proBNP in a cross-sectional study.Methods:Among 664 participants (mean age, 61.9 years; female, 70.5%) from a general Japanese population without a history of heart disease, 86 (13.0%) had NT-proBNP at least 125 pg/ml.Results:Each 1 SD increase in the SD of home systolic BP (SBP)[odds ratio (OR), 1.82; P<. 0001) and in the SD of home HR (OR, 1.44; P= 0.008) were significantly associated with the prevalence of NT-proBNP at least 125 pg/ml after adjustment for possible confounding factors including home SBP and HR. Among the four groups defined by the median SD of home SBP and of home HR, the group with higher SDs in home SBP (≥ 8.0 mmHg) and HR (≥ 5.0 bpm) had the greatest OR for the prevalence of NT-proBNP at least 125 pg/ml (OR, 4.80; P= 0007 vs. a reference group with lower SDs of home SBP and HR).Conclusion:These results suggest that day-to-day variability in BP and HR may be associated with target-organ damage or complications, which can lead to an elevated NT-proBNP level. An elevated NT-proBNP level may be involved in the prognostic significance of day-to-day variability in BP or HR.