Viral infection of the trophoblast: time to take a serious look at its role in abnormal implantation and placentation?
Viral infection of the trophoblast: time to take a serious look at its role in abnormal implantation and placentation?
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DOI：
10.1016/s0165-0378(01)00143-7
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发表时间：
2002-05-01
影响因子：
3.4
通讯作者：
Parry, S
中科院分区：
文献类型：
--
作者：
Arechavaleta-Velasco, F;Koi, H;Parry, S
零星证据表明滋养层病毒感染可能在胎盘功能障碍中起作用，导致并发症，包括自发性流产、先兆子痫、胎儿生长受限和早产。在这里，我们回顾滋养层细胞的分化和孕龄依赖性感染的机制和滋养层功能的体外感染的后果。本文还分析了常见病毒感染与妊娠结局的关系。我们的结论是，有足够的证据表明，胎盘感染的常见病毒，包括病毒被认为是非致病性或具有低致病性，表明这种影响有助于不良妊娠结局。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
Fragmentary evidence suggests that trophoblast viral infection may play a role in placental dysfunction, leading to complications including spontaneous miscarriage, preeclampsia, fetal growth restriction and preterm birth. Here, we review the mechanisms underlying differentiation and gestational age-dependent infection of trophoblast cells and the consequences of in vitro infection on trophoblast function. The relationship between trophoblast infection by common viruses and pregnancy outcomes is also analyzed. We conclude that there is sufficient evidence linking placental infection by common viruses, including viruses thought to be non-pathogenic or to have low pathogenicity, to indicate that this effect contributes to poor pregnancy outcome. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.