BEHAVIORAL-ASPECTS OF CLINICAL-TRIALS - AN INTEGRATED FRAMEWORK FROM BEHAVIOR-THEORY
BEHAVIORAL-ASPECTS OF CLINICAL-TRIALS - AN INTEGRATED FRAMEWORK FROM BEHAVIOR-THEORY
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DOI：
10.1002/cncr.1994.2820740918
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发表时间：
1994-11-01
期刊：
影响因子：
6.2
通讯作者：
BURISH, TG
中科院分区：
文献类型：
--
作者：
MORROW, GR;HICKOK, JT;BURISH, TG
在美国国家癌症研究所（National cancer institute）资助的临床试验中，癌症患者的比例并不理想。本文回顾了肿瘤临床试验中应计收益的文献，以描述问题的程度，确定低应计收益的原因，并提出促进应计收益的方法。四个著名的健康行为理论（健康信念模型、主观预期效用理论、保护动机理论和理性行为理论）指出了理解患者健康相关行为所涉及的核心概念：(1)不受欢迎的健康事件发生在患者身上的概率，(2)如果确实发生了，该事件的严重程度，(3)特定行为（如参加临床试验）对改变严重程度的有效性，以及(4)采取该行为的成本。这些概念形成了一个框架，用于整合有关临床肿瘤学试验的可获得信息。先前与临床试验相关的患者和医生因素建议增加临床肿瘤试验的应计收益。
A less-than-optimal proportion of patients with cancer are entered into National Cancer Institute-sponsored clinical trials. This article reviews the literature on accrual in oncology clinical trials to characterize the extent of the problem, identify reasons for low accrual, and suggest ways to promote accrual. Four well known theories of health behavior (the Health Belief Model, Subjective Expected Utility Theory, Protection Motivation Theory, and the Theory of Reasoned Action) point to central concepts involved in understanding patient health-related behavior: (1) the probability that an unwelcomed health event will happen to a patient, (2) the severity of that event if it does occur, (3) the effectiveness of a particular behavior (such as taking part in a clinical trial) to modify the severity, and (4) the cost of adopting that behavior. These concepts form a framework for integrating the available information about accrual to clinical oncology trials. Patient and physician factors previously related to clinical trials suggest specific recommendations for increasing accrual to clinical oncology trials.