Differentiating among prefrontal substrates in psychopathy: Neuropsychological test findings
Differentiating among prefrontal substrates in psychopathy: Neuropsychological test findings
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DOI：
10.1037/0894-4105.20.2.153
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发表时间：
2006-03-01
期刊：
影响因子：
2.4
通讯作者：
Blair, RJR
中科院分区：
文献类型：
--
作者：
Blair, KS;Newman, C;Blair, RJR
额叶和随之而来的执行功能障碍一直与精神病有关。最近，有人提出，额叶皮层的特定区域，而不是整个额叶皮层，可能与精神病有关。为了研究这个问题，作者提出了25个精神病患者和30个对照个体，其测量优先索引眶额皮质（OFC;对象交替任务），背外侧前额叶皮质（DLPFC;空间交替任务）和前扣带回皮质（ACC;数字Stroop阅读和计数任务）。精神病患者在对眶额皮层功能优先敏感的测量指标上表现出明显的损害。相比之下，2组没有表现出损害的措施优先敏感的DLPFC或ACC. These结果解释的功能障碍的执行功能障碍帐户。
Frontal lobe and consequent executive dysfunction have long been related to psychopathy. More recently, there have been suggestions that specific regions of frontal cortex, rather than all of frontal cortex, may be implicated in psychopathy. To examine this issue, the authors presented 25 individuals with psychopathy and 30 comparison individuals with measures preferentially indexing the orbitofrontal cortex (OFC; object alternation task), dorsolateral prefrontal cortex (DLPFC; spatial alternation task), and anterior cingulate cortex (ACC; number-Stroop reading and counting tasks). The individuals with psychopathy showed significant impairment on the measure preferentially sensitive to OFC functioning. In contrast, the 2 groups did not show impairment on the measures preferentially sensitive to the functioning of the DLPFC or ACC. These results are interpreted with reference to executive dysfunction accounts of the disorder.