High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: The JPHC study
High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: The JPHC study
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DOI：
10.1016/j.atherosclerosis.2012.01.013
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发表时间：
2012-04-01
期刊：
影响因子：
5.3
通讯作者：
Tsugane, Shoichiro
中科院分区：
文献类型：
--
作者：
Cui, Renzhe;Iso, Hiroyasu;Tsugane, Shoichiro
背景：在西方国家，高血清总胆固醇水平是缺血性中风的危险因素。然而，在中风发病率较高的亚洲人群中，这种相关性还没有得到彻底的调查。方法：参与者为11,727名男性和21,742名女性，年龄在40-69岁之间，在基线水平上都没有心血管疾病和癌症。在中位数12年的随访中，我们记录了612例缺血性卒中(腔隙性脑梗塞293例，大动脉闭塞性脑梗塞107例，栓塞性脑梗塞168例)。结果：血清总胆固醇水平为6.21 mmol/L的男性患者发生缺血性中风的风险高于血清总胆固醇水平最低的患者(<；4.65 mmol/L)，而女性则没有。男性的多变量危险比(HR)和95%可信区间(95%CI)分别为1.63(1.14-2.35)和1.03(0.69-1.55)。大动脉闭塞性脑梗死组的相应HR值男性为2.86(1.31~6.27)，女性为0.75(0.28~2.01)。无论男女，血清总胆固醇水平与腔隙或栓塞性脑梗塞的风险均无相关性。结论：高血清总胆固醇是日本男性缺血性卒中，尤其是大动脉闭塞性脑梗塞的危险因素。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Background: High serum total cholesterol levels represent a risk factor of ischemic stroke in Western countries. However, this association has not been thoroughly investigated in Asian populations where the incidence of stroke is high.Methods: Participants were 11,727 men and 21,742 women aged 40-69 years, all free of cardiovascular disease and cancer at baseline. During the median 12-year follow-up, we documented 612 ischemic stroke (293 lacunar infarction, 107 large-artery occlusive infarctions, and 168 embolic infarctions).Results: Excess risk of ischemic stroke was observed in men with serum total cholesterol levels of >= 6.21 mmol/L than those with the lowest category (< 4.65 mmol/L), but not in women. The multivariable hazard ratios (HRs) and 95% confidence interval (95% CI) were 1.63 (1.14-2.35) for men and 1.03 (0.69-1.55) for women. The corresponding HRs of large-artery occlusive infarction were 2.86 (1.31-6.27) for men and 0.75 (0.28-2.01) for women. Serum total cholesterol levels were not associated with risk of lacunar or embolic infarction for either sex.Conclusions: High serum total cholesterol is a risk factor of ischemic stroke, specifically large-artery occlusive infarction for Japanese men. (C) 2012 Elsevier Ireland Ltd. All rights reserved.