Naloxone microinjected into the arcuate nucleus has differential effects on ventilation in male and female rats.
Naloxone microinjected into the arcuate nucleus has differential effects on ventilation in male and female rats.
复制标题
纳洛酮显微注射到弓状核中对雄性和雌性大鼠的通气具有不同的影响。
DOI：
10.1016/s0031-9384(97)80330-7
复制
发表时间：
1997
影响因子：
2.9
通讯作者：
Egland,MC
中科院分区：
文献类型：
--
作者：
Schlenker,EH;Martin,DS;Lin,XM;Egland,MC
Schlenker，E. H.，D. S. Martin，X. M. Lin 和 M. C. Egland。纳洛酮显微注射到弓状核中对雄性和雌性大鼠的通气具有不同的影响。 Physiol Behav 62(3) 531–536, 1997。——下丘脑的弓状核是一个高度性别二态性的大脑区域，被称为内源性阿片类药物的床核。尚未研究阿片类药物在该核中对调节雄性和雌性大鼠通气控制的潜在贡献。本研究的目的是确定将纳洛酮（一种阿片受体拮抗剂）显微注射到清醒雄性和雌性大鼠的弓状核中对通气、耗氧量、心率和血压的影响。这项研究的结果表明，相对于赋形剂而言，剂量为1.5和3.0 nmol的纳洛酮由于雄性大鼠的呼吸频率和潮气量降低以及雌性大鼠对高碳酸血症的反应降低而导致通气抑制。尽管在耗氧量、心率、血压和对缺氧挑战的通气反应方面存在性别差异，但只有耗氧量受到纳洛酮的显着影响。讨论了纳洛酮抑制通气的潜在机制。
Schlenker, E. H., D. S. Martin, X. M. Lin and M. C. Egland. Naloxone microinjected into the arcuate nucleus has differential effects on ventilation in male and female rats. Physiol Behav 62(3) 531–536, 1997.—The arcuate nucleus of the hypothalamus, a highly sexually dimorphic brain region, has been called the bed nucleus for endogenous opioids. The potential contribution of opioids in this nucleus to modulate control of ventilation in male and female rats has not been investigated. The purpose of the present study is to determine the effect of microinjecting naloxone, an opioid receptor antagonist, into the arcuate nucleus of awake male and female rats on ventilation, oxygen consumption, heart rate, and blood pressure. Results of this study demonstrate that naloxone at doses of 1.5 and 3.0 nmol relative to vehicle caused a depression of ventilation due to a decrease of both frequency of breathing and tidal volume in male rats and a decreased response to a hypercapnic challenge in female rats. Although there were gender differences noted in oxygen consumption, heart rate, blood pressure, and ventilatory response to a hypoxic challenge, only oxygen consumption was significantly affected by naloxone. Potential mechanisms whereby naloxone may act to depressing ventilation are discussed.