Estimation of age-specific sensitivity and sojourn time in breast cancer screening studies
Estimation of age-specific sensitivity and sojourn time in breast cancer screening studies
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DOI：
10.1002/sim.2178
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发表时间：
2005-10-30
影响因子：
2
通讯作者：
Miller, AB
中科院分区：
文献类型：
--
作者：
Cong, XYJ;Shen, Y;Miller, AB
本研究采用统计学方法定量描述乳腺癌筛查研究中年龄对筛查敏感性和滞留时间分布的影响。这种调查的直接动机是需要了解年龄和这些重要数量之间的内在关系。我们在渐进疾病建模框架下通过广义线性模型纳入年龄效应，并使用极大似然方法获得相应的参数估计量。在一组潜在模型中，我们使用Akeike信息准则和似然比检验进行模型选择和推断。大量的仿真研究表明，该估计器具有合理的精度和良好的模型选择准则。所提出的方法是用两个大型乳腺癌筛查试验的数据来说明的。结果表明，在这两项试验的基础上，筛查的敏感性随着年龄的增长而增加。版权所有(C) 2005 John Wiley & Sons, Ltd。
This study investigates statistical approaches to quantitatively describing the age effect on screening sensitivity and sojourn time distribution in breast cancer screening studies. Such an investigation is directly motivated by the need to understand the inherent relationships between age and these important quantities. We incorporate the age effect through generalized linear models under a progressive disease modelling framework and obtain the corresponding parameter estimators using the maximum likelihood method. Among a set of potential models, we use Akeike's information criterion and likelihood ratio test in model selection and inferences. Extensive simulation studies show that the estimators have reasonable accuracy and the model selection criterion works well. The proposed methods are illustrated using data from two large breast cancer screening trials. The results show that the screening sensitivity increases with age at screening examinations based on these two trials. Copyright (C) 2005 John Wiley & Sons, Ltd.