Fibrin glue for persistent pneumothorax in neonates.
Fibrin glue for persistent pneumothorax in neonates.
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DOI：
10.1038/sj.jp.7210852
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Herson, Victor
中科院分区：
文献类型：
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作者：
Sarkar, Shikha;Hussain, Naveed;Herson, Victor
使用止血胶治疗8名新生儿平均持续10天的严重气胸。8名婴儿中有6名在治疗后24小时内持续漏气减少或消失。两名婴儿因复发接受了第二疗程治疗。出现的并发症包括需要手动通气的心动过缓（N=2）、显著高钙血症（N=2）、痉挛性麻痹（N=2）、对侧气胸（PTX）（N=1）和局部组织坏死（N=1）。粘合剂是治疗难治性PTX的有效方法，但具有显著的风险。
Fibrin glue was used to treat significant pneumothoraces persisting for an average of 10 days in eight newborns. Six of the eight infants had reduction or resolution of persistent air leak within 24 hours of therapy. Two infants received a second course of therapy for recurrences. Complications encountered were bradycardia requiring manual ventilation (N=2), significant hypercalcemia (N=2), diaphragmatic paralysis (N=2), pneumothorax (PTX) on the contralateral side (N=1), and localized tissue necrosis (N=1). Fibrin glue is an effective treatment for intractable PTX but has significant risks.