Effects of proton pump inhibitors on calcium carbonate absorption in women: A randomized crossover trial
Effects of proton pump inhibitors on calcium carbonate absorption in women: A randomized crossover trial
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DOI：
10.1016/j.amjmed.2005.02.007
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发表时间：
2005-07-01
影响因子：
5.9
通讯作者：
Kerzner, LJ
中科院分区：
文献类型：
--
作者：
O'Connell, MB;Madden, DM;Kerzner, LJ
较高的钙摄入量与骨质流失减少有关，(1) 较低的钙吸收与骨折风险增加有关。(2) 因为美国人的平均饮食中钙含量不足，(3) 大多数美国人需要补充钙。(4) pH 在钙吸收中的作用存在争议，并且由于食物的影响而引起混淆，食物会改变胃的 pH 值和胃肠道蠕动。体外碳酸钙崩解和溶解取决于 pH 值；随着pH值的增加，崩解和溶解减慢，从pH为1时的96%下降到pH 6.1时的23%。(5)质子泵抑制剂可有效减少胃酸产生并增加胃pH值。在最近的一项研究中，每日服用奥美拉唑将胃部 pH 值从 1.3 增加至 5.5，(6) 一天中 19% 的时间 pH 值高于 6。(7) 因此，本研究的目的是确定质子泵抑制剂的酸抑制是否会减少钙吸收。
Higher calcium intakes have been associated with decreased bone loss,(1) and lower calcium absorption has been associated with increased fracture risk.(2) Because the average American diet contains insufficient calcium,(3) Most Americans require calcium supplementation.(4)The role of pH in calcium absorption is controversial and confounded by food effects, which alter stomach pH and gastrointestinal motility. In vitro calcium carbonate disintegration and dissolution is pH dependent; as pH increases, disintegration and dissolution slows, decreasing from 96% at a pH of 1, to 23% at pH 6.1.(5) Proton pump inhibitors effectively reduce gastric acid production and increase gastric pH. In a recent study, daily omeprazole increased the me- than stomach pH from 1.3 to 5.5,(6) with 19% of the day spent above a pH of 6.(7) Therefore, the purpose of this study was to determine if acid suppression from proton pump inhibitors would decrease calcium absorption.