Materials for engineering vascularized adipose tissue
Materials for engineering vascularized adipose tissue
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DOI：
10.1016/j.jtv.2009.11.005
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发表时间：
2011-05-01
影响因子：
2.5
通讯作者：
Brey, Eric M.
中科院分区：
文献类型：
--
作者：
Chiu, Yu-Chieh;Cheng, Ming-Huei;Brey, Eric M.
脂肪组织的损失可由于先天性和获得性脂肪萎缩、创伤、肿瘤切除和慢性疾病而发生。在临床上，脂肪组织很难再生或重建。脂肪中广泛存在的微血管网络，以及脂肪细胞对缺氧的敏感性，阻碍了典型组织移植手术的成功。促进血管化脂肪组织形成的材料可能为目前的临床治疗方案提供替代方案。研究了组织工程中常用的一些合成和天然生物材料作为脂肪再生的支架。虽然这些材料显示出一些希望，但它们并不能解释脂肪独特的细胞外微环境。脂肪源性水凝胶更接近脂肪组织的物理和化学微环境，在体外促进脂肪前细胞分化和血管组装，在体内刺激血管化脂肪的形成。这些材料与促进快速和稳定血管形成的技术相结合，可能会导致用于临床应用的工程稳定，血管化脂肪组织的新技术。本文综述了用于脂肪组织工程的材料及其血管化策略。临床意义：促进血管化脂肪组织形成的材料有潜力作为现有治疗方案的替代或补充，用于慢性疾病、脂肪萎缩、创伤和肿瘤切除引起的脂肪缺陷或缺陷。(C) 2009组织活力学会。Elsevier Ltd.出版。版权所有。
Loss of adipose tissue can occur due to congenital and acquired lipoatrophies, trauma, tumor resection, and chronic disease. Clinically, it is difficult to regenerate or reconstruct adipose tissue. The extensive microvsacular network present in adipose, and the sensitivity of adipocytes to hypoxia, hinder the success of typical tissue transfer procedures. Materials that promote the formation of vascularized adipose tissue may offer alternatives to current clinical treatment options. A number of synthetic and natural biomaterials common in tissue engineering have been investigated as scaffolds for adipose regeneration. While these materials have shown some promise they do not account for the unique extracellular microenvironment of adipose. Adipose derived hydrogels more closely approximate the physical and chemical microenvironment of adipose tissue, promote preadipocyte differentiation and vessel assembly in vitro, and stimulate vascularized adipose formation in vivo. The combination of these materials with techniques that promote rapid and stable vascularization could lead to new techniques for engineering stable, vascularized adipose tissue for clinical application. In this review we discuss materials used for adipose tissue engineering and strategies for vascularization of these scaffolds.Clinical Relevance: Materials that promote formation of vascularized adipose tissue have the potential to serve as alternatives or supplements to existing treatment options, for adipose defects or deficiencies resulting from chronic disease, lipoatrophies, trauma, and tumor resection. (C) 2009 Tissue Viability Society. Published by Elsevier Ltd. All rights reserved.