Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors.
Comparison of labeled MIBG and somatostatin analogs in imaging neuroendocrine tumors.
复制标题
标记 MIBG 和生长抑素类似物在神经内分泌肿瘤成像中的比较。
DOI：
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
M. Salvatore
中科院分区：
文献类型：
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作者：
S. Lastoria;S. Maurea;E. Vergara;W. Acampa;P. Varrella;M. Klain;P. Muto;J. Bernardy;M. Salvatore
在10例经组织学证实的神经内分泌肿瘤（4例类癌，4例嗜铬细胞瘤，1例甲状腺髓样癌和1例默克尔瘤）中，比较了放射性标记的间碘苄胍（MIBG）和生长抑素类似物的结果。在标准成像研究中共检测到24个肿瘤病灶。MIBG血管造影正确定位了5例患者（4例嗜铬细胞瘤和1例类癌）中的12例（50%）病变。使用标记的生长抑素类似物的闪烁成像正确定位了8例患者（4例类癌，2例嗜铬细胞瘤，1例甲状腺髓样癌和1例默克尔瘤）中的21个（87%）病变。在1例类癌和2例嗜铬细胞瘤患者中获得了一致的造影结果。总之，虽然这一系列是有限的，我们的结果表明，MIBG是更准确的比生长抑素类似物在成像嗜铬细胞瘤。相反，生长抑素类似物在检测其他神经内分泌肿瘤如类癌时比MIBG更准确。
In 10 patients with histologically proven neuroendocrine tumors (4 carcinoids, 4 pheochromocytomas, 1 medullary thyroid cancer and 1 Merkel tumor) the results of radiolabeled metaiodobenzylguanidine (MIBG) and somatostatin analogs were compared. A total of 24 tumor lesions was detected on standard imaging studies. MIBG scintigraphy correctly localized 12 (50%) of these lesions which were observed in 5 patients (4 with pheochromocytoma and 1 with carcinoid tumor). Scintigraphy using labeled somatostatin analogs correctly localized 21 (87%) lesions which occurred in 8 patients (4 with carcinoid, 2 with pheochromocytoma, 1 with medullary thyroid cancer and 1 with Merkel tumor). Concordant scintigraphic results were obtained in 1 patient with carcinoid and 2 with pheochromocytoma. In conclusion, although this series was limited, our results suggest that MIBG is more accurate than somatostatin analogs in imaging pheochromocytoma. Conversely, somatostatin analogs are more accurate than MIBG in detecting other neuroendocrine tumors such as carcinoids.