The structural alteration of gut microbiota in low-birth-weight mice undergoing accelerated postnatal growth.
The structural alteration of gut microbiota in low-birth-weight mice undergoing accelerated postnatal growth.
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出生后加速生长的低出生体重小鼠肠道微生物群的结构变化。
DOI：
10.1038/srep27780
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发表时间：
2016-06-09
影响因子：
4.6
通讯作者：
Shen J
中科院分区：
文献类型：
--
作者：
Wang J;Tang H;Wang X;Zhang X;Zhang C;Zhang M;Zhao Y;Zhao L;Shen J
抗生素在婴儿时期对肠道微生物区系的短暂破坏会导致成年小鼠肥胖。出生后生长加速(A)导致低出生体重(LB)人群比正常出生体重(NB)人群患成人代谢综合征的风险更高，但其潜在机制尚不清楚。在这里，我们建立了一个实验，使用了LB + A小鼠，NB + A小鼠，并以出生后正常生长的NB小鼠为对照。在24周龄(成年)时，与对照组相比，NB + A组动物的体脂含量和糖耐量正常，而LB + A组小鼠表现出过度肥胖和糖耐量异常。在婴儿期，与肥胖有关的粪便细菌在LB + A幼鼠中比在NB + A幼鼠中增加，包括硫磺弧菌科、肠杆菌和巴氏杆菌。来自乳杆菌属的一种细菌，被认为与预防成年肥胖有关，只在NB + A幼崽中得到增强。此外，LB + A仔猪表现出肠道微生物区系发酵活性紊乱，而NB + A仔猪则没有。断奶后，24周时，LB + A组小鼠的粪便微生物区系组成与对照组相似，而NB + A组小鼠的粪便微生物区系组成与对照组相似。在婴儿期，与NB + A小鼠相比，LB + A小鼠具有更多的肠道微生物群失调，这可能会增加它们患成年代谢综合征的风险。
The transient disruption of gut microbiota in infancy by antibiotics causes adult adiposity in mice. Accelerated postnatal growth (A) leads to a higher risk of adult metabolic syndrome in low birth-weight (LB) humans than in normal birth-weight (NB) individuals, but the underlying mechanism remains unclear. Here, we set up an experiment using LB + A mice, NB + A mice, and control mice with NB and normal postnatal growth. At 24 weeks of age (adulthood), while NB + A animals had a normal body fat content and glucose tolerance compared with controls, LB + A mice exhibited excessive adiposity and glucose intolerance. In infancy, more fecal bacteria implicated in obesity were increased in LB + A pups than in NB + A pups, including Desulfovibrionaceae, Enterorhabdus, and Barnesiella. One bacterium from the Lactobacillus genus, which has been implicated in prevention of adult adiposity, was enhanced only in NB + A pups. Besides, LB + A pups, but not NB + A pups, showed disrupted gut microbiota fermentation activity. After weaning, the fecal microbiota composition of LB + A mice, but not that of NB + A animals, became similar to that of controls by 24 weeks. In infancy, LB + A mice have a more dysbiotic gut microbiome compared to NB + A mice, which might increase their risk of adult metabolic syndrome.