Associate Editor: D. Shugar The 90-kDa Molecular Chaperone Family: Structure, Function, and Clinical Applications. A Comprehensive Review
Associate Editor: D. Shugar The 90-kDa Molecular Chaperone Family: Structure, Function, and Clinical Applications. A Comprehensive Review
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发表时间：
1998
影响因子：
4
通讯作者：
P. Csermely;T. Schnaider;Z. Prohászka;G. Nardai
中科院分区：
文献类型：
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作者：
P. Csermely;T. Schnaider;Z. Prohászka;G. Nardai
90-kDa分子伴侣家族（其中包括90- kDa热休克蛋白，hsp 90和94-kDa葡萄糖调节蛋白，grp 94，分别是胞质溶胶和内质网的主要分子伴侣）在过去几年中已成为日益活跃的研究主题。这些普遍存在的、高度保守的蛋白质占大多数细胞中所有细胞蛋白质的1-2%。然而，它们的确切功能还远未阐明。它们参与几种自身免疫性疾病的病因学、各种感染、识别恶性细胞和抗原呈递，已经证明了它们可能在未来十年的临床实践中发挥重要作用。本文综述了90 kDa分子伴侣家族的细胞功能、表达和临床意义，并展望了今后的研究方向。Pharmacol. ther. 79（2）：129-168，1998.© 1998 Elsevier Science Inc.
The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90- kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major molecular chaperones of the cytosol and of the endoplasmic reticulum, respectively) has become an increasingly active subject of research in the past couple of years. These ubiquitous, well-conserved proteins account for 1-2% of all cellular proteins in most cells. However, their precise function is still far from being elucidated. Their involvement in the aetiology of several autoimmune diseases, in various infections, in recognition of malignant cells, and in antigen-presentation already demonstrates the essential role they likely will play in clinical practice of the next decade. The present review summarizes our current knowledge about the cellular functions, expression, and clinical implications of the 90-kDa molecular chaperone family and some approaches for future research. pharmacol. ther. 79(2):129-168, 1998. © 1998 Elsevier Science Inc.