TRANSPORT AND METABOLISM OF POLYAMINES IN HUMAN-LYMPHOCYTES
TRANSPORT AND METABOLISM OF POLYAMINES IN HUMAN-LYMPHOCYTES
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DOI：
10.1016/0020-711x(90)90262-2
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发表时间：
1990-01-01
期刊：
影响因子：
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通讯作者：
GRILLO, MA
中科院分区：
文献类型：
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作者：
COLOMBATTO, S;FASULO, L;GRILLO, MA
1.人外周血淋巴细胞通过能量依赖性转运系统以浓度、时间和pH依赖性方式摄取多胺。2.除了腐胺外，每种多胺都抑制其他多胺的吸收。精胺似乎对运输具有最高的亲和力。3.哇巴因，amyloride和钒酸盐的抑制表明，运输依赖于Na+。4.细胞内的多胺含量在与亚精胺或精胺孵育期间分别增加约6倍和3倍。5.掺入的多胺部分地相互转化。
1. Polyamines are taken up by human peripheral lymphocytes in a concentration, time and pH dependent manner, with an energy-dependent transport system. 2. Each polyamine inhibits the uptake of the others, with the exception of putrescine. Spermine appears to have the highest affinity for the transport/s. 3. Inhibition by ouabain, amyloride and vanadate suggests that the transport is dependent on Na+. 4. Polyamine content inside the cells increases by ca 6 and 3 times respectively during incubation with spermidine or spermine. 5. The incorporated polyamines are partially transformed into each other.