Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.
Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline.
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DOI：
10.1016/j.neurobiolaging.2017.04.006
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发表时间：
2017-08
影响因子：
4.2
通讯作者：
Holland AJ
中科院分区：
文献类型：
--
作者：
Cole JH;Annus T;Wilson LR;Remtulla R;Hong YT;Fryer TD;Acosta-Cabronero J;Cardenas-Blanco A;Smith R;Menon DK;Zaman SH;Nestor PJ;Holland AJ
患有唐氏综合症（DS）的人更有可能更早地经历多个方面的生理衰老。这包括脑萎缩、β淀粉样蛋白沉积、认知能力下降和阿尔茨海默病——这些都是大脑衰老的迹象。在这里，我们采用了机器学习方法，使用结构神经影像数据来预测 DS 患者 (N = 46) 和典型发育对照者 (N = 30) 的年龄（即大脑预测年龄）。然后从大脑预测的年龄中减去实际年龄，以生成大脑预测的年龄差异（brain-PAD）评分。 DS 参与者还接受了 [11C]-PiB 正电子发射断层扫描 (PET) 扫描，以索引大脑 β 淀粉样蛋白沉积的水平，并进行认知评估。 DS 参与者的平均 Brain-PAD 为 +2.49 年，显着高于对照组 (p < 0.001)。大脑 PAD 的变异性与 PiB 结合的存在和程度以及认知能力水平相关。我们的研究表明 DS 与过早的大脑结构老化有关，并且与年龄相关的大脑结构改变与 β 淀粉样蛋白沉积率和认知障碍的个体差异有关。
Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive decline, and Alzheimer's disease—factors indicative of brain aging. Here, we employed a machine learning approach, using structural neuroimaging data to predict age (i.e., brain-predicted age) in people with DS (N = 46) and typically developing controls (N = 30). Chronological age was then subtracted from brain-predicted age to generate a brain-predicted age difference (brain-PAD) score. DS participants also underwent [11C]-PiB positron emission tomography (PET) scans to index the levels of cerebral beta amyloid deposition, and cognitive assessment. Mean brain-PAD in DS participants' was +2.49 years, significantly greater than controls (p < 0.001). The variability in brain-PAD was associated with the presence and the magnitude of PiB-binding and levels of cognitive performance. Our study indicates that DS is associated with premature structural brain aging, and that age-related alterations in brain structure are associated with individual differences in the rate of beta amyloid deposition and cognitive impairment.