Pneumonectomy for non-small cell lung cancer
Pneumonectomy for non-small cell lung cancer
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DOI：
10.1007/s00595-012-0174-0
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发表时间：
2012-09-01
期刊：
影响因子：
2.5
通讯作者：
Yasuda, Manabu
中科院分区：
文献类型：
--
作者：
Ichiki, Yoshinobu;Nagashima, Akira;Yasuda, Manabu
为了评估非小细胞肺癌（NSCLC）全肺切除术的死亡率、并发症和主要发病率，并确定各种预后因素的重要性，我们回顾性分析了1992年至2007年期间71例接受全肺切除术的NSCLC患者的住院记录，以评估不良结局的危险因素的重要性。根据治疗时间分为早期（1992-1999年; n = 47）和晚期（2000-2007年; n = 24）两个时期组，30 d和住院死亡率均为4.2%（3/71）。并发症发生率为31.3%（22/71），5年生存率为23.1%。病理III期或以上、T3期或以上、N2期或以上是不良结局的危险因素。生存率不受组织学类型、手术侧或治愈性的显著影响。早期和晚期的5年生存率分别为19.6%和32.9%。早期临床N2或3期患者多于晚期患者（66.0 vs. 33.3%）。阑尾切除术与可接受的总体发病率和死亡率相关;然而，病理分期III或以上、T3或以上以及N2或以上疾病的患者需要特别考虑。结肠切除术应仅在选定的患者中进行。
To assess the mortality, complications and major morbidity of pneumonectomy for non-small cell lung cancer (NSCLC) and to establish the importance of various prognostic factors.We reviewed retrospectively the hospital records of 71 consecutive patients who underwent pneumonectomy for NSCLC between 1992 and 2007 to evaluate the significance of risk factors for an adverse outcome. Patients were divided into two period groups according to the period when they were treated: early (1992-1999; n = 47) and late (2000-2007; n = 24).Both the 30-day and the in-hospital mortality rates were 4.2 % (3/71). Complications developed in 31.3 % (22/71) and overall 5-year survival was 23.1 %. Pathological stage III or more, T3 or more, and N2 or more were risk factors of an adverse outcome. Survival was not significantly influenced by histological type, the side of surgery, or curability. The 5-year survival rates for the early and late periods were 19.6 and 32.9 %, respectively. There were more patients with clinical N2 or 3 disease in the early period than in the late period (66.0 vs. 33.3 %).Pneumonectomy is associated with acceptable overall morbidity and mortality; however, patients with pathological stage III or more, T3 or more, and N2 or more disease require special consideration. Pneumonectomy should be performed only in selected patients.