STRESS INCREASES RENAL NERVE ACTIVITY AND DECREASES SODIUM-EXCRETION IN DAHL RATS
STRESS INCREASES RENAL NERVE ACTIVITY AND DECREASES SODIUM-EXCRETION IN DAHL RATS
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DOI：
10.1161/01.hyp.11.4.334
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发表时间：
1988-04-01
期刊：
影响因子：
8.3
通讯作者：
DIBONA, GF
中科院分区：
文献类型：
--
作者：
KOEPKE, JP;JONES, S;DIBONA, GF
在清醒的Dahl盐敏感（DS）和Dahl盐耐受（DR）大鼠中，研究了低（0.4%）和高（8%）NaCl饮食的应激环境刺激（空气应激）对平均动脉压、肾交感神经活动和肾功能的影响。空气压力增加肾交感神经活动，降低尿流率和尿钠排泄清醒的达尔大鼠高钠饮食，但它对大鼠低钠饮食没有影响。平均动脉压在任何组的空气压力期间均未发生变化。去肾神经可防止DS和DR在高NaCl饮食下对空气应激的抗利尿和抗利尿反应。肾小管对钠和水的重吸收增加似乎介导了DS和DR在高NaCl饮食下对空气应激的抗利尿和抗利尿反应。肾小管对钠和水的重吸收增加似乎介导了对空气应激的抗利尿和抗利尿反应，因为肾小球滤过率和肾血浆流量不变。因此，环境应激增加肾交感神经活动和减少尿钠排泄量更多的达尔大鼠高NaCl饮食比低NaCl饮食。在高NaCl饮食中，DS的这些反应大于DR。
The effects of a stressful environmental stimulus (air stress) on mean arterial pressure, renal sympathetic nerve activity, and renal function were examined in conscious Dahl salt-sensitive (DS) and Dahl salt-resistant rats (DR) on low (0.4%) and high (8%) NaCl diets. Air stress increased renal sympathetic nerve activity and decreased urine flow rate and urinary sodium excretion in conscious Dahl rats on a high sodium diet, but it had no effect in rats on a low sodium diet. Mean arterial pressure did not change during air stress in any group. Renal denervation prevented the antidiuretic and antinatriuretic responses to air stress in DS and DR on a high NaCl diet. An increased renal tubular reabsorption of sodium and water appeared to mediate the antinatriuretic and antidiuretic responses to air stress in DS and DR on a high NaCl diet. An increased renal tubular reabsorption of sodium and water appeared to mediate the antinatriuretic and antidiuretic responses to air stress, since glomerular filtration rate and renal plasma flow were unchanged. Thus, environmental stress increases renal sympathetic nerve activity and decreases urinary sodium excretion more in Dahl rats on a high NaCl diet than on a low NaCl diet. On a high NaCl diet, these responses are greater in DS than in DR.