Autopsy case of prostate cancer with multiple endocrine neoplasia 2A
Autopsy case of prostate cancer with multiple endocrine neoplasia 2A
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DOI：
10.1111/j.1440-1827.2004.01773.x
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发表时间：
2004-12-01
影响因子：
2.2
通讯作者：
Konishi, N
中科院分区：
文献类型：
--
作者：
Ishida, E;Nakamura, M;Konishi, N
我们描述了一个65岁的男子与前列腺癌伴随多发性内分泌肿瘤2A（MEN 2A），包括恶性嗜铬细胞瘤，甲状腺髓样癌和甲状旁腺增生的尸检病例。原发性和转移性嗜铬细胞瘤的前列腺转移性病变通过免疫组化检测前列腺特异性抗原来确定。为了研究前列腺癌对嗜铬细胞瘤细胞的亲和力，使用许多抗体进行免疫组织化学，两种肿瘤均为N-钙粘蛋白阳性。有趣的是，嗜铬细胞瘤、甲状腺髓样癌和前列腺癌的抗RET抗体均呈阳性。免疫组化结果表明，细胞的亲和力可能，部分，通过N-钙粘蛋白的细胞-细胞粘附。虽然前列腺癌很少与MEN相关，但RET激活可能参与了该病例的肿瘤发生。
We describe an autopsy case of a 65-year-old man with prostate cancer accompanied by multiple endocrine neoplasia 2A (MEN 2A), including malignant pheochromocytomas, thyroid medullary carcinomas and parathyroid hyperplasia. Metastatic lesions from the prostate primary were identified using immunohistochemistry for prostate specific antigen within both primary and metastatic pheochromocytomas in the liver. To investigate the affinity of prostate cancer for pheochromocytoma cells, immunohistochemistry was carried out using a number of antibodies and both tumors were positive for N-cadherin. Interestingly, pheochromocytomas, thyroid medullary carcinomas and prostate cancer were all positive for the anti-RET antibody. The immunohistochemical results suggest that the cell affinity may, in part, result from cell-cell adhesion via N-cadherin. Although prostate cancer is rarely associated with MEN, RET activation may have participated in the tumorigenesis of this case.