SMOKING AND SYMPTOM EFFECTS ON THE CURVES OF LUNG-FUNCTION GROWTH AND DECLINE
SMOKING AND SYMPTOM EFFECTS ON THE CURVES OF LUNG-FUNCTION GROWTH AND DECLINE
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DOI：
10.1164/ajrccm/144.1.17
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发表时间：
1991-07-01
期刊：
影响因子：
--
通讯作者：
BURROWS, B
中科院分区：
文献类型：
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作者：
SHERRILL, DL;LEBOWITZ, MD;BURROWS, B
大量研究考察了人一生中肺功能增长和衰退的自然时间过程。 在大多数这些研究中，研究人员使用的统计模型需要对肺功能数据的基本形式或结构进行先验假设，从而引入可能的偏差。 在这项研究中，我们使用最近开发的非参数回归（样条）技术来描述肺功能测量值随年龄的演变。 该过程通过数据和过程速度的估计产生最佳拟合的平滑曲线，并且不需要关于数据曲线的基本形状的假设。 肺功能生长速度曲线用于估计生长停止的年龄。 该技术应用于 1,295 名女性和 1,230 名男性的 FVC、FEV1 和 FEV1/FVC 比值，这些人在图森气道阻塞性疾病流行病学研究的前 9 项调查中至少有一项进行了测试。 根据性别、吸烟状况和呼吸道症状或疾病对数据进行分层分析。 结果表明，与无症状非吸烟者相比，各个亚组的拟合 FEV1 和 FEV1/FVC 平滑曲线之间存在很大差异。 这些差异在有症状的成年吸烟者中最为明显，无论男女，他们的肺功能丧失率都较高，而且这种情况也开始于较早的年龄。 无症状和有症状的非吸烟者之间没有观察到显着差异，很可能是因为有症状的非吸烟者数量减少，尤其是男性。
Numerous studies have examined the natural time course of human lung function growth and decline throughout life. In most of these studies the investigators used statistical models that required a priori assumptions concerning the underlying form or structure of the lung function data, thus introducing possible biases. In this study we used recently developed nonparametric regression (spline) techniques to describe the evolution of lung function measures with age. This procedure yields an optimally fitted smooth curve through the data and estimates of the process velocity and dose not require assumptions concerning the underlying shape of the data curves. The lung function growth-velocity curves are used to estimate the age of growth cessation. This technique was applied to the FVC, FEV1, and the FEV1/FVC ratios of 1,295 females and 1,230 males who were tested in at least one of the first nine surveys of the Tucson epidemiologic study of airway obstructive diseases. Data were analyzed stratified according to gender, smoking status, and respiratory symptoms or diseases. The results indicate large differences between the fitted FEV1 and FEV1/FVC smoothed curves of the various subgroups compared with asymptomatic nonsmokers. These differences were most pronounced in the adult symptomatic smokers, who had higher rates of lung function loss that also began at earlier ages, for both sexes. No significant differences were observed between asymptomatic and symptomatic nonsmokers, most likely because of the reduced number of symptomatic nonsmokers, particularly among the males.