Functional Anatomy of Basal Ganglia Circuits with the Cerebral Cortex and the Cerebellum.
Functional Anatomy of Basal Ganglia Circuits with the Cerebral Cortex and the Cerebellum.
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DOI：
10.1159/000480748
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Strick, Peter L
中科院分区：
文献类型：
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作者：
Bostan, Andreea C;Dum, Richard P;Strick, Peter L
基底神经节的神经连接为其功能提供了重要的见解。在这里，我们讨论了目前关于基底神经节与大脑皮层和小脑连接的观点。我们回顾了基底神经节参与大脑皮层运动和非运动区域的功能分离回路的证据。然后我们讨论了基底神经节与小脑相互联系的数据。这些结果为基底神经节不仅对运动控制，而且对各种认知和情感功能的贡献提供了解剖学基础。此外，这些发现表明，与大脑皮层和小脑相关的基底神经节回路的异常活动可能导致与几种神经和精神疾病相关的运动和非运动缺陷。
The neural connections of the basal ganglia provide important insights into their function. Here, we discuss the current perspective on basal ganglia connections with the cerebral cortex and with the cerebellum. We review the evidence that the basal ganglia participate in functionally segregated circuits with motor and non-motor areas of the cerebral cortex. We then discuss the data that the basal ganglia are interconnected with the cerebellum. These results provide the anatomical substrate for basal ganglia contributions not only to the control of movement, but also to a variety of cognitive and affective functions. Furthermore, these findings indicate that abnormal activity in basal ganglia circuits with the cerebral cortex and with the cerebellum may contribute to both motor and non-motor deficits associated with several neurologic and psychiatric conditions.