ApoE genotype and abnormal auditory cortical potentials in healthy older females.
ApoE genotype and abnormal auditory cortical potentials in healthy older females.
复制标题
健康老年女性的 ApoE 基因型和异常听觉皮层电位。
DOI：
10.1016/j.neurobiolaging.2008.09.005
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发表时间：
2010
影响因子：
4.2
通讯作者：
Starr,Arnold
中科院分区：
文献类型：
--
作者：
Irimajiri,Rie;Golob,EdwardJ;Starr,Arnold
载脂蛋白E （ApoE）水平和性别是阿尔茨海默病发展的危险因素。与携带apoe4基因的男性相比，阿尔茨海默病在女性中更为普遍。我们检测了女性听觉目标检测任务中皮质感觉（P50, N100）和认知（P300）电位作为ApoE基因型（ApoE ε 4携带者，ApoE ε 4非携带者）的功能，以确定在认知障碍临床表达之前异常的发生率。两个ApoE组的神经心理测试分数和感觉皮质电位没有差异。与非ApoE携带者相比，ApoE携带者的认知P300电位幅度明显下降，潜伏期明显延迟。10名ApoE ε 4携带者中有4名出现异常（bbb2sd）的P300延迟，而20名非携带者中只有1名。P300潜伏期延迟反映的异常认知过程在携带该等位基因的正常老年女性中表达的发生率明显高于非携带该等位基因的女性。
Apolipoprotein E (ApoE) status and gender are risk factors for the development of Alzheimer’s disease. Alzheimer’s disease is more prevalent in female relative to male carriers of the ApoE ɛ4 gene. We examined cortical sensory (P50, N100) and cognitive (P300) potentials in an auditory target detection task in females as a function of ApoE genotype (ApoE ɛ4 carriers, ApoE ɛ4 non-carriers) to define the incidence of abnormalities prior to the clinical expression of cognitive impairments. Both neuropsychological test scores and sensory cortical potentials did not differ between the two ApoE groups. In contrast, cognitive P300 potentials were significantly decreased in amplitude and delayed in latency for ApoE ɛ4 carriers compared to non-carriers. Four out of the 10 ApoE ɛ4 carriers had abnormally (>2S.D.) delayed P300 latency compared to one out of 20 non-carriers. Abnormal cognitive processes reflected by P300 latency delays are expressed at significantly higher incidence in normal older females who are carriers of the ɛ4 allele than in non-carriers of this allele.