Plasma homovanillic acid concentration and the severity of schizophrenic illness.
Plasma homovanillic acid concentration and the severity of schizophrenic illness.
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血浆高香草酸浓度和精神分裂症的严重程度。
DOI：
10.1126/science.3975630
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Horvath,TB
中科院分区：
文献类型：
--
作者：
Davis,KL;Davidson,M;Mohs,RC;Kendler,KS;Davis,BM;Johns,CA;DeNigris,Y;Horvath,TB
治疗前血浆高香草酸浓度与精神分裂症患者治疗前后的总体病情严重程度高度相关。相反，固定剂量的氟哌啶醇不影响这些浓度。因此，在诊断为精神分裂症的患者中，血浆高香草酸可能反映疾病的严重程度，但不受精神抑制剂的短期药理学干扰的影响。
Concentrations of plasma homovanillic acid before treatment were highly correlated with global severity of illness in schizophrenic patients, both before and after treatment. In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic acid may reflect the severity of illness, but not be influenced by short-term pharmacological perturbations by neuroleptics.