C-REACTIVE PROTEIN - A CLINICAL MARKER IN COMMUNITY-ACQUIRED PNEUMONIA
C-REACTIVE PROTEIN - A CLINICAL MARKER IN COMMUNITY-ACQUIRED PNEUMONIA
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DOI：
10.1378/chest.108.5.1288
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发表时间：
1995-11-01
期刊：
影响因子：
9.6
通讯作者：
WINTER, JH
中科院分区：
文献类型：
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作者：
SMITH, RP;LIPWORTH, BJ;WINTER, JH
研究目的：评估社区获得性肺炎患者血浆c反应蛋白（CRP）的范围，并比较该急性期蛋白的系列变化与临床结果。设计：前瞻性基于医院的研究，包括单独的回顾性病例系列。患者：对28例连续住院的社区获得性肺炎患者（平均年龄60岁）进行了研究。每日连续采集血浆样本，检测CRP、肿瘤坏死因子- α (tnf - α)和白细胞介素6 (IL-6)，记录临床参数、实验室数据和对治疗的反应。另外4例被认为抗生素治疗失败的患者（3例脓胸，1例死亡）分别进行了研究。结果：2例患者死亡。在存活的患者中，第1、2、3、4和5天的平均（+/-SD） CRP值如下：136+/- 43,96 +/- 44,53 +/- 36,54 +/-43和44+/-31 mg/L。入院前接受抗生素治疗的患者第1天CRP水平显著低于未接受抗生素治疗的患者，分别为107+/-42和152+/-44 mg/L (p
Study objective: To assess the range of plasma C-reactive protein (CRP) in patients presenting with community-acquired pneumonia and to compare the serial changes of this acute-phase protein with clinical outcome.Design: Prospective hospital-based study, including separate retrospective case series.Patients: Twenty-eight consecutive patients (mean age, 60 years) admitted to our hospital with community-acquired pneumonia were studied. Serial daily plasma samples were taken and assayed for CRP, tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6), Clinical parameters, laboratory data, and response to treatment were recorded. Four other patients considered to be antibiotic failures (three empyemas, one death) were studied separately.Results: Two patients died. Of those who survived, mean (+/-SD) CRP values for days 1, 2, 3, 4, and 5 were as follows: 136+/-43, 96+/-44, 53+/-36, 54+/-43, and 44+/-31 mg/L. CRP levels on day 1 in patients who had received antibiotics prior to hospital admission were significantly lower than those who had not, 107+/-42 and 152+/-44 mg/L (p