A functional scaffold of CNS neurons for the vertebrates: the developing Xenopus laevis spinal cord.
A functional scaffold of CNS neurons for the vertebrates: the developing Xenopus laevis spinal cord.
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脊椎动物中枢神经系统神经元的功能支架：正在发育的非洲爪蟾脊髓。
DOI：
10.1002/dneu.20889
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发表时间：
2012
影响因子：
3
通讯作者：
Roberts A
中科院分区：
文献类型：
--
作者：
Roberts A
在幼年和发育中的两栖动物和鱼类中，脊髓是有功能的，但与成年动物相比非常简单。神经元的模式和它们的连接至少在这些低等脊椎动物中是共同的吗？这种基本模式是否延伸到脑干？简单功能神经网络的发展是否依赖于非常基本的连接规则，并作为先驱网络，为更复杂和微妙的网络的发展提供基础？在这次审查的功能神经元类theXenopus laevistadpole脊髓孵化，我们将考虑的进展和困难，使用解剖，转录因子的表达，生理和活动，以确定脊髓神经元类型。即使在这里，它也不是直截了当的，而且几乎不可能把所有不同的证据放在一起。但是，我们认为我们对孵化蝌蚪的脊髓神经元类型有了一个相当完整的了解，并且可以为它们中的大多数在行为中定义明确的角色。我们目前对刚孵化的异种脊髓的了解，应该为将来通过更多面向发育的研究来解决许多问题奠定了基础。© 2011 Wiley Periodicals，Inc.开发神经生物学72：575-584，2012年
In young and developing amphibians and fish the spinal cord is functional but remarkably simple compared with the adult. Is the pattern of neurons and their connections common across at least these lower vertebrates? Does this basic pattern extend into the brainstem? Could the development of simple functioning neuronal networks depend on very basic rules of connectivity and act as pioneer networks providing a substrate for the development of more complex and subtle networks. In this review of the functional neuron classes in theXenopus laevistadpole spinal cord up to hatching, we will consider progress and difficulties in using anatomy, transcription factor expression, physiology, and activity to define spinal neuron types. Even here it is not straightforward and is rarely possible to bring all the different strands of evidence together. But, we think we have a rather complete picture of the hatchling tadpole spinal neuron types and can define clear roles for most of them in behavior. Our present knowledge about the hatchlingXenopusspinal cord should set up many of the problems to be unraveled in the future by more developmentally oriented research. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 72: 575–584, 2012