Peptide/protein-based macrocycles: from biological synthesis to biomedical applications.
Peptide/protein-based macrocycles: from biological synthesis to biomedical applications.
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基于肽/蛋白质的大环：从生物合成到生物医学应用。
DOI：
10.1039/d1cb00246e
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发表时间：
2022-07-06
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
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生物体已经进化出环状或多环肽和蛋白质，其稳定性和生物活性优于线性肽和蛋白质，可用于多种用途。在此，我们回顾了将这一概念应用于人工肽和蛋白质以利用这些大环化合物的功能优势的最新进展。不仅制备了简单的循环形式，还开发了许多大环变体，例如结和环。总结了这些大环化合物的生物合成的化学工具和合成策略，证明其是化学合成的强大替代方案。其在治疗性肽/蛋白质中的进一步应用使得生物医药的药物性能得到了显着改善。最后，我们提出了对该领域及其未来发展的看法。基于肽和蛋白质的大环化合物已通过生物合成和进化，具有增强的稳定性和高生物活性，在多种生物医学应用中优于其线性对应物。
Living organisms have evolved cyclic or multicyclic peptides and proteins with enhanced stability and high bioactivity superior to their linear counterparts for diverse purposes. Herein, we review recent progress in applying this concept to artificial peptides and proteins to exploit the functional benefits of these macrocycles. Not only have simple cyclic forms been prepared, numerous macrocycle variants, such as knots and links, have also been developed. The chemical tools and synthetic strategies are summarized for the biological synthesis of these macrocycles, demonstrating it as a powerful alternative to chemical synthesis. Its further application to therapeutic peptides/proteins has led to biomedicines with profoundly improved pharmaceutical performances. Finally, we present our perspectives on the field and its future developments. Peptide- and protein-based macrocycles have been biologically synthesized and evolved with enhanced stability and high bioactivity that are superior to their linear counterparts for diverse biomedical applications.