Influence of Lime Juice on the Severity of Sickle Cell Anemia
Influence of Lime Juice on the Severity of Sickle Cell Anemia
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DOI：
10.1089/acm.2012.0567
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发表时间：
2013-06-01
影响因子：
2.6
通讯作者：
Oyelami, Oyeku Akibu
中科院分区：
文献类型：
--
作者：
Adegoke, Samuel Ademola;Shehu, Umar Abdullahi;Oyelami, Oyeku Akibu
背景和目的：镰状细胞性贫血（SCA）的疼痛通常由疟疾引起的脱水、酸中毒和发热引起。最近的研究表明，摄入酸橙汁有助于清除疟原虫。因此，研究人员试图确定定期摄入酸橙汁是否会改善危机，尤其是复发性骨痛。设计：在这个初步的、开放标记的、随机的研究中，我们测试了酸橙汁对SCA儿童的临床和一些实验室特征的影响。结果：在两家医院研究的113名SCA儿童中，58名接受石灰治疗的儿童明显疼痛发作的发生率低于55名未接受石灰治疗的儿童（6个月内37次对83次，平均每名儿童0.64 +/- 0.11比1.51 +/- 0.34,p < 0.001）。此外，与对照组相比，有明显疼痛发作的受试者较少（50.0%对92.7%）；发热性疾病（46.6%对87.3%）和住院率（3.4%对34.5%）（p < 0.001）。研究结束时，受试者的平均血细胞比容（26.23±2.03%）也较高，p < 0.001。然而，输血率、肝肿大、脾肿大和黄疸的存在是相似的。用石灰治疗没有引起任何明显的副作用。结论：定期摄入酸橙汁可能对SCA患儿具有重要的治疗和营养意义。
Background and objectives: The pain in sickle cell anemia (SCA) is often triggered by dehydration, acidosis, and fever that are usually due to malaria. Intake of lime juice was recently demonstrated to facilitate clearance of the malaria parasite. It was therefore sought to determine whether regular intake of lime juice will ameliorate crisis, especially recurrent bone pain.Design: In this preliminary, open-labeled, randomized study, the effects of lime juice on the clinical and some laboratory characteristics of children with SCA were tested.Results: Among the 113 children with SCA studied in two hospitals, the 58 receiving lime treatment had lower rates of significant painful episodes than the 55 without lime (37 versus 83 crises in 6 months, and 0.64 +/- 0.11 versus 1.51 +/- 0.34 average rates per child, p < 0.001). Also, fewer subjects than the controls had significant painful episodes (50.0% versus 92.7%); febrile illness (46.6% versus 87.3%) and admission rate (3.4% versus 34.5%) (p < 0.001). The mean hematocrit of the subjects (26.23 +/- 2.03%) at the end of the study was also higher, p < 0.001. However, transfusion rate, presence of hepatomegaly, splenomegaly, and jaundice was similar. Treatment with lime did not cause any significant side-effect.Conclusions: Regular intake of lime juice may be of great therapeutic and nutritional relevance in children with SCA.