Kernicterus in neonates from ethnic minorities in the UK.
Kernicterus in neonates from ethnic minorities in the UK.
复制标题
英国少数民族新生儿的核黄疸。
DOI：
10.1136/archdischild-2022-324642
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Baskaran D
中科院分区：
文献类型：
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作者：
Baskaran D
核黄疸（胆红素脑病）是终身神经残疾的重要原因，英国的发病率为0.9/100 000活产。1它会导致疼痛性肌张力障碍，限制随意运动，影响言语和听力，但通常会保留认知能力。这种影响反映在成功索赔的高费用上。2令人不安的是，在英国，非白人群体受到的影响不成比例。来自英国少数民族群体的新生儿患高胆红素血症的风险很高。一般的风险因素包括胎龄< 38周，打算只母乳喂养，在最初24小时内发生黄疸和/或黄疸进展。在某些群体中，溶血性疾病，如葡萄糖6磷酸脱氢酶（G6 PD）缺乏症的患病率增加。在英国/爱尔兰的一项严重新生儿高胆红素血症监测研究中，只有48%被确定为“白人”。1
Kernicterus(bilirubin encephalopathy) is an important cause of lifelong neurodisability, with UK incidence of 0.9/100 000 live births. 1 It causes painful dystonia, limits voluntary movements and affects speech and hearing, though often preserving cognition. The impact is reflected in the high cost of successful claims. 2 Disturbingly, non-white ethnic groups are disproportionately affected in the UK.Neonates from UK ethnic minority groups are at high risk of hyperbilirubinaemia. General risk factors include gestational age< 38 weeks, intention to solely breast feed, jaundice with onset in the first 24 hours and/or progression of jaundice. In some groups, haemolytic diseases such as glucose 6 phosphate dehydrogenase (G6PD) deficiency have increased prevalence. In a UK/Ireland surveillance study of severe neonatal hyperbilirubinaemia, only 48% were identified as ‘white’. 1