Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries.
Workgroup report: public health strategies for reducing aflatoxin exposure in developing countries.
复制标题
工作组报告：减少发展中国家黄曲霉毒素暴露的公共卫生策略。
DOI：
10.1289/ehp.9302
复制
发表时间：
2006-12
影响因子：
10.4
通讯作者：
Wilson, David
中科院分区：
文献类型：
--
作者：
Strosnider, Heather;Azziz-Baumgartner, Eduardo;Banziger, Marianne;Bhat, Ramesh V;Breiman, Robert;Brune, Marie-Noel;DeCock, Kevin;Dilley, Abby;Groopman, John;Hell, Kerstin;Henry, Sara H;Jeffers, Daniel;Jolly, Curtis;Jolly, Pauline;Kibata, Gilbert N;Lewis, Lauren;Liu, Xiumei;Luber, George;McCoy, Leslie;Mensah, Patience;Miraglia, Marina;Misore, Ambrose;Njapau, Henry;Ong, Choon-Nam;Onsongo, Mary T K;Page, Samuel W;Park, Douglas;Patel, Manish;Phillips, Timothy;Pineiro, Maya;Pronczuk, Jenny;Rogers, Helen Schurz;Rubin, Carol;Sabino, Myrna;Schaafsma, Arthur;Shephard, Gordon;Stroka, Joerg;Wild, Christopher;Williams, Jonathan T;Wilson, David
2004年和2005年，肯尼亚连续爆发急性黄曲霉中毒，造成150人死亡。作为回应，美国疾病控制与预防中心和世界卫生组织于2005年7月在瑞士日内瓦召集了一个由国际专家和卫生官员组成的工作组。在讨论了关于黄曲霉毒素的已知情况之后，工作组确定了目前在黄曲霉毒素对人类健康的急性和慢性影响、监测和食品监测、分析方法以及干预策略的有效性方面的知识差距。工作组还确定了可与目前的农业方法相结合的公共卫生战略，以解决目前知识方面的差距，并最终降低发展中国家与消费受黄曲霉毒素污染的食品有关的发病率和死亡率。确定了需要立即关注的四个问题：a)量化接触黄曲霉毒素对人类健康的影响和疾病负担；B)编制一份清单，评估正在进行的干预策略的有效性，并传播结果；C)发展和加强受影响地区的疾病监测、食品监测、实验室和公共卫生应对能力；d)制定可在急性黄曲霉中毒暴发时使用的反应方案。本报告扩展了工作组关于发展中国家黄曲霉毒素的讨论，并总结了研究结果。
Consecutive outbreaks of acute aflatoxicosis in Kenya in 2004 and 2005 caused > 150 deaths. In response, the Centers for Disease Control and Prevention and the World Health Organization convened a workgroup of international experts and health officials in Geneva, Switzerland, in July 2005. After discussions concerning what is known about aflatoxins, the workgroup identified gaps in current knowledge about acute and chronic human health effects of aflatoxins, surveillance and food monitoring, analytic methods, and the efficacy of intervention strategies. The workgroup also identified public health strategies that could be integrated with current agricultural approaches to resolve gaps in current knowledge and ultimately reduce morbidity and mortality associated with the consumption of aflatoxin-contaminated food in the developing world. Four issues that warrant immediate attention were identified: a) quantify the human health impacts and the burden of disease due to aflatoxin exposure; b) compile an inventory, evaluate the efficacy, and disseminate results of ongoing intervention strategies; c) develop and augment the disease surveillance, food monitoring, laboratory, and public health response capacity of affected regions; and d) develop a response protocol that can be used in the event of an outbreak of acute aflatoxicosis. This report expands on the workgroup’s discussions concerning aflatoxin in developing countries and summarizes the findings.