Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces.
Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces.
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DOI：
10.1038/nmat4673
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发表时间：
2016-09
期刊：
影响因子：
41.2
通讯作者：
Tian B
中科院分区：
文献类型：
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作者：
Jiang Y;Carvalho-de-Souza JL;Wong RC;Luo Z;Isheim D;Zuo X;Nicholls AW;Jung IW;Yue J;Liu DJ;Wang Y;De Andrade V;Xiao X;Navrazhnykh L;Weiss DE;Wu X;Seidman DN;Bezanilla F;Tian B
硅基材料作为生物物理工具和生物医学设备有着广泛的应用。在这里，我们介绍了一种生物相容和可降解的介观结构形式的硅具有多尺度结构和化学异质性。以介孔二氧化硅为模板剂，采用化学气相沉积法制备了该材料。它具有无定形的原子结构、有序的纳米线骨架和随机的亚微米空洞，并且显示出比单晶硅小2-3个数量级的平均杨氏模数。此外，我们利用异质硅介观结构设计了一种脂类双层支持的生物电界面，该界面是远程控制的和瞬时的，并允许对单个背根神经节神经元的电生理动力学进行非遗传和亚细胞光学调制。我们的发现表明，硅的仿生扩展成异质和可变形的形式可以在细胞外生物材料或生物电子系统中打开机会。
Silicon-based materials have widespread application as biophysical tools and biomedical devices. Here we introduce a biocompatible and degradable mesostructured form of silicon with multiscale structural and chemical heterogeneities. The material was synthesized using mesoporous silica as a template through a chemical-vapor-deposition process. It has an amorphous atomic structure, an ordered nanowire-based framework, and random submicrometre voids, and shows an average Young’s modulus that is 2–3 orders of magnitude smaller than that of single crystalline silicon. In addition, we used the heterogeneous silicon mesostructures to design a lipid-bilayer-supported bioelectric interface that is remotely controlled and temporally transient, and that permits non-genetic and subcellular optical modulation of the electrophysiology dynamics in single dorsal root ganglia neurons. Our findings suggest that the biomimetic expansion of silicon into heterogeneous and deformable forms can open up opportunities in extracellular biomaterial or bioelectric systems.