Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure:: an open study
Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure:: an open study
复制标题
DOI：
10.1016/s0140-6736(98)06423-x
复制
发表时间：
1999-04-17
期刊：
影响因子：
168.9
通讯作者：
Hasenfuss, G
中科院分区：
文献类型：
--
作者：
Hermann, HP;Pieske, B;Hasenfuss, G
Background Pyruvate, as an intermediate in the Krebs cycle, is an important source of energy for myocardium and improves contractility of normal, hypoxic, and postischaemic animal myocardium. We investigated the effect of intracoronary pyruvate in patients with congestive heart failure.Methods Haemodynamic measurements were done in eight patients with dilated cardiomyopathy after two 15 min infusions of pyruvate into the left main coronary artery and after saline washout of pyruvate.Findings There were no significant differences between the two pyruvate concentrations. Application of pyruvate resulted in a 23% increase in cardiac index (p
