Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates
Nickel-Catalyzed Biaryl Coupling of Heteroarenes and Aryl Halides/Triflates
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DOI：
10.1021/ol9001587
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发表时间：
2009-04-16
期刊：
影响因子：
5.2
通讯作者：
Itami, Kenichiro
中科院分区：
文献类型：
--
作者：
Canivet, Jerome;Yamaguchi, Junichiro;Itami, Kenichiro
已经建立了用于杂芳烃与芳基卤化物和三氟甲磺酸酯芳基化的镍基催化系统。 Ni(OAc)(2)/bipy 是芳基溴/芳基碘化物的通用催化剂，Ni(OAC)(2)/dppf 对于芳基氯/三氟甲磺酸酯有效。噻唑、苯并噻唑、恶唑、苯并恶唑和苯并咪唑可用作杂芳烃偶联配偶体。还证明了非布索坦（一种治疗痛风和高尿酸血症的药物）的快速合成。
Ni-based catalytic systems for the arylation of heteroarenes with aryl halides and triflates have been established. Ni(OAc)(2)/bipy is a general catalyst for aryl bromides/iodides, and Ni(OAC)(2)/dppf is effective for aryl chlorides/triflates. Thiazole, benzothiazole, oxazole, benzoxazole, and benzimidazole are applicable as heteroarene coupling partners. A rapid synthesis of febuxostat, a drug for gout and hyperuricemia, is also demonstrated.