Infrared-Emitting QDs for Thermal Therapy with Real-Time Subcutaneous Temperature Feedback
Infrared-Emitting QDs for Thermal Therapy with Real-Time Subcutaneous Temperature Feedback
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DOI：
10.1002/adfm.201601953
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发表时间：
2016-09-06
影响因子：
19
通讯作者：
Jaque, Daniel
中科院分区：
文献类型：
--
作者：
del Rosal, Blanca;Carrasco, Elisa;Jaque, Daniel
如今，纳米技术在生物医学中最令人兴奋的应用之一是为各种疾病（如癌症）开发局部非侵入性疗法。其中，基于纳米粒子的光热疗法（PTT），其通过在注入活体样本中的纳米探针的光激发时传递热量来破坏恶性细胞，正在以巨大的潜力出现。PTT成为可行的临床治疗必须达到的两个主要里程碑是触发光学激发的深度穿透和正在进行的治疗的实时准确温度监测，这构成了最大限度地减少附带损害的关键因素。在这项工作中，展示了近红外发射半导体纳米晶体（量子点，QD）尚未探索的能力。首次提出了利用PbS/CdS/ZnS量子点在第二生物窗口发光的温度自监测的基于量子点的PTT。这些QD能够同时充当光热剂（加热器）和高分辨率荧光热传感器，使得能够在PTT期间实现对肿瘤内温度增量的完全控制。通过不同的照射条件，在这项全面的研究中观察到的肿瘤内和表面温度之间的差异，突出了对肿瘤内温度的实时控制的需要，允许动态调整治疗条件，以最大限度地提高治疗效果。
Nowadays, one of the most exciting applications of nanotechnology in biomedicine is the development of localized, noninvasive therapies for diverse diseases, such as cancer. Among them, nanoparticle-based photothermal therapy (PTT), which destroys malignant cells by delivering heat upon optical excitation of nanoprobes injected into a living specimen, is emerging with great potential. Two main milestones that must be reached for PTT to become a viable clinical treatment are deep penetration of the triggering optical excitation and real-time accurate temperature monitoring of the ongoing therapy, which constitutes a critical factor to minimize collateral damage. In this work, a yet unexplored capability of near-infrared emitting semiconductor nanocrystals (quantum dots, QDs) is demonstrated. Temperature self-monitored QD-based PTT is presented for the first time using PbS/CdS/ZnS QDs emitting in the second biological window. These QDs are capable of acting, simultaneously, as photothermal agents (heaters) and high-resolution fluorescent thermal sensors, making it possible to achieve full control over the intratumoral temperature increment during PTT. The differences observed between intratumoral and surface temperatures in this comprehensive investigation, through different irradiation conditions, highlight the need for real-time control of the intratumoral temperature that allows for a dynamic adjustment of the treatment conditions in order to maximize the efficacy of the therapy.