Terpenoid Biosynthesis Off the Beaten Track: Unconventional Cyclases and Their Impact on Biomimetic Synthesis
Terpenoid Biosynthesis Off the Beaten Track: Unconventional Cyclases and Their Impact on Biomimetic Synthesis
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DOI：
10.1002/anie.201407883
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发表时间：
2015-02-23
影响因子：
16.6
通讯作者：
Hertweck, Christian
中科院分区：
文献类型：
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作者：
Baunach, Martin;Franke, Jakob;Hertweck, Christian
萜烯和萜类化合物环化反应是自然界中最复杂的化学反应之一，对这个最大的天然产物家族的巨大结构多样性起着至关重要的作用。许多研究在化学、遗传和生物化学水平上进行，以获得对这些由萜烯和萜类化合物环化酶催化的有趣反应的机理见解。这些酶中的无数种已经被表征。经典的教科书知识根据萜烯/萜类化合物环化酶的结构和反应机理将其分为两大类。然而，最近发现的新类型的萜类环化酶说明，自然界的酶的剧目是远远超过最初认为的多样性。这篇综述概述了新的萜类化合物环化酶是不寻常的。
Terpene and terpenoid cyclizations are counted among the most complex chemical reactions occurring in nature and contribute crucially to the tremendous structural diversity of this largest family of natural products. Many studies were conducted at the chemical, genetic, and biochemical levels to gain mechanistic insights into these intriguing reactions that are catalyzed by terpene and terpenoid cyclases. A myriad of these enzymes have been characterized. Classical textbook knowledge divides terpene/terpenoid cyclases into two major classes according to their structure and reaction mechanism. However, recent discoveries of novel types of terpenoid cyclases illustrate that nature's enzymatic repertoire is far more diverse than initially thought. This Review outlines novel terpenoid cyclases that are out of the ordinary.