pH-Triggered nanoreactors as oxidative stress amplifiers for combating multidrug-resistant biofilms.
pH-Triggered nanoreactors as oxidative stress amplifiers for combating multidrug-resistant biofilms.
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DOI：
10.1039/d1cc00247c
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发表时间：
2021-04
影响因子：
4.9
通讯作者：
Lei Huang;Shangming Jiang;Bo Cai;Guobin Wang;Zheng Wang;Lin Wang
中科院分区：
文献类型：
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作者：
Lei Huang;Shangming Jiang;Bo Cai;Guobin Wang;Zheng Wang;Lin Wang
开发产生自由基氧物种(ROS)的纳米反应器作为新的“抗生素”是治疗多药耐药(MDR)生物被膜感染的一种有前途的策略。在这里，我们设计并制备了银纳米颗粒修饰的过氧化钙(CaO2)纳米反应器(CPA)，用于对抗MDR生物膜。在酸性生物膜中，CPA可以通过pH触发和自催化的方式局部促进ROS的产生，其中H2O2通过CaO2的水解释放出来，并被Ag NPs原位催化生成O2·-，从而有效地破坏成熟的生物膜并杀灭细菌。
Developing radical oxygen species (ROS)-generating nanoreactors as new "antibiotics" is a promising strategy for the treatment of multidrug-resistant (MDR) biofilm infections. Herein, we designed and fabricated silver nanoparticle-decorated calcium peroxide (CaO2) nanoreactors (CPA) for combating MDR biofilms. CPA could locally boost ROS production as oxidative stress amplifiers in a pH-triggered and self-catalytic manner in acidic biofilms, where H2O2 was released by the hydrolysis of CaO2 and sequentially catalyzed by Ag NPs in situ to generate O2˙-, thereby efficiently disrupting mature biofilms and killing bacteria.