Cutaneous arteritis associated with peripheral neuropathy: two case reports
Cutaneous arteritis associated with peripheral neuropathy: two case reports
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与周围神经病变相关的皮肤动脉炎：两例报告
DOI：
10.1111/1346-8138.12416
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发表时间：
2014
期刊：
影响因子：
3.1
通讯作者：
Sobue G
中科院分区：
文献类型：
--
作者：
Riku Y;Ikenaka K;Koike H;Niimi Y;Senda J;Hashimoto R;Kawagashira Y;Tomita M;Iijima M;Sobue G
Dear Editor, Primary vasculitis confined to a single organ without systemic manifestation is referred to as single organ vasculitis (SOV). 1 SOV that affects the skins or peripheral nerves has been named cutaneous arteritis or non-systemic vasculitic neuropathy (NSVN), respectively. 1–3 These isolated vasculitides predominantly affect middle-or small-sized vessels within the lower dermis or epineurium and show relatively benign prognosis obtained by immunosuppressive therapies. 2, 3 We describe two cases of necrotizing vasculitis confined to the skin and peripheral nerves and discuss pathogenetic relationship between these isolated vasculitides. Case 1 was a 24-year-old woman who presented with sensory disturbance, progressive weakness, and pain in her hands and feet, which had started 3 months prior. Chemical exposure, daily alcohol consumption and a history of diabetes mellitus were absent. On admission, the skin of the lower extremities demonstrated multiple livedo reticularis, purpura and tenderness (Fig. 1a–b). The weakness and sensory disturbance showed a pattern of mononeuritis multiplex predominantly in her left foot, which was supported by electrophysiological studies. Other constitutional symptoms were absent. Routine examinations of blood chemistry, urine and cerebrospinal fluid were normal. Tests for eosinophil count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), thiamine, anti-immunoglobulin (Ig) G cardiolipin, anti-IgG prothrombin, anti-SS-A/B, anti-DNA, anti-Sm, antineutrophil cytoplasmic antibodies, lupus anticoagulants, cryoglobulins,(a)(f)(g)(h)(i)(j)(b)(c)(d)(e)
