Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women - The Nurses' Health Study
Body fat distribution and risk of non-insulin-dependent diabetes mellitus in women - The Nurses' Health Study
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DOI：
10.1093/oxfordjournals.aje.a009158
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发表时间：
1997-04-01
影响因子：
5
通讯作者：
Manson, JE
中科院分区：
文献类型：
--
作者：
Carey, VJ;Walters, EE;Manson, JE
肥胖是非胰岛素依赖型糖尿病（NIDDM）的既定危险因素。作为 NIDDM 风险预测因子的整体肥胖和中心性肥胖的人体测量指标尚未得到充分研究，特别是在女性中。在 1986 年参加护士健康研究的 43,581 名女性中，她们提供了腰部、臀部和体重信息，并且最初没有糖尿病和其他主要慢性疾病，我们对 1986 年至 1994 年的 NIDDM 发病率进行了跟踪。在调整年龄、糖尿病家族史、吸烟、运动和多种饮食因素后，体重指数 (BMI)（体重（kg）/身高）第 90 个百分位数的 NIDDM 相对风险(m)(2)) (BMI = 29.9) 与第 10 个百分位数 (BMI = 20.1) 相比为 11.2（95% 置信区间 (CI) 7.9-15.9）。控制 BMI 和其他潜在的混杂因素，腰臀比 (WHR) (WHR = 0.86) 第 90 个百分位数 (WHR = 0.70) 与第 10 个百分位数 (WHR = 0.70) 的相对风险为 3.1 (95% CI 2.3-4.1)，腰围第 90 个百分位数（36.2 英寸或 92 厘米）与第 10 个百分位数相比的相对风险（26.2 英寸或 67 厘米）为 5.1（95% CI 2.9-8.9），BMI、腰臀比和腰围是美国女性 NIDDM 的强大独立预测因子。BMI 和腰围（有或没有臀围）的测量可能是临床医生为患者提供有关 NIDDM 风险和降低风险咨询的有用工具。
Obesity is an established risk factor for non-insulin-dependent diabetes mellitus (NIDDM). Anthropometric measures of overall and central obesity as predictors of NIDDM risk have not been as well studied, especially in women. Among 43,581 women enrolled in the Nurses' Health Study who in 1986 provided waist, hip, and weight information and who were initially free from diabetes and other major chronic diseases, NIDDM incidence was followed from 1986 to 1994. After adjustment for age, family history of diabetes, smoking, exercise, and several dietary factors, the relative risk of NIDDM for the 90th percentile of body mass index (BMI) (weight (kg)/height (m)(2)) (BMI = 29.9) versus the 10th percentile (BMI = 20.1) was 11.2 (95% confidence interval (CI) 7.9-15.9). Controlling for BMI and other potentially confounding factors, the relative risk for the 90th percentile of waist : hip ratio (WHR) (WHR = 0.86) versus the 10th percentile (WHR = 0.70) was 3.1 (95% CI 2.3-4.1), and the relative risk for the 90th percentile of waist circumference (36.2 inches or 92 cm) versus the 10th percentile (26.2 inches or 67 cm) was 5.1 (95% CI 2.9-8.9), BMI, WHR, and waist circumference are powerful independent predictors of NIDDM in US women, Measurement of BMI and waist circumference (with or without hip circumference) are potentially useful tools for clinicians in counseling patients regarding NIDDM risk and risk reduction.