Clinical significance of exosomes as potential biomarkers in cancer
Clinical significance of exosomes as potential biomarkers in cancer
复制标题
外泌体作为癌症潜在生物标志物的临床意义
DOI：
10.12998/wjcc.v7.i2.171
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发表时间：
2019-01
期刊：
影响因子：
--
通讯作者：
Yang-Chao Chen
中科院分区：
文献类型：
--
作者：
Chi-Hin Wong;Yang-Chao Chen
BACKGROUND Exosomes are microvesicles, measuring 30-100 nm in diameter. They are widely distributed in body fluids, including blood, bile, urine and saliva. Cancer-derived exosomes carry a wide variety of DNA, RNA, proteins and lipids, and may serve as novel biomarkers in cancer. AIM To summarize the performance of exosomal biomarkers in cancer diagnosis and prognosis. METHODS Relevant publications in the literature were identified by search of the “PubMed” database up to September 11, 2018. The quality of the included studies was assessed by QUADAS-2 and REMARK. For assessment of diagnostic biomarkers, 47 biomarkers and 2240 patients from 30 studies were included. RESULTS Our results suggested that these exosomal biomarkers had excellent diagnostic ability in various types of cancer, with good sensitivity and specificity. For assessment of prognostic markers, 50 biomarkers and 4797 patients from 42 studies were included. We observed that exosomal biomarkers had prognostic values in overall survival, disease-free survival and recurrence-free survival. CONCLUSION Exosomes can function as potential biomarkers in cancer diagnosis and prognosis.
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