Glucagonoma syndrome and necrolytic migratory erythema
Glucagonoma syndrome and necrolytic migratory erythema
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DOI：
10.1111/j.1365-4632.2009.04220.x
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发表时间：
2010-01-01
影响因子：
3.6
通讯作者：
Carvalho, Rui
中科院分区：
文献类型：
--
作者：
Lobo, Ines;Carvalho, Andre;Carvalho, Rui
The glucagonoma syndrome is a rare disorder, characterized by necrolytic migratory erythema, elevated serum glucagon levels, abnormal glucose tolerance, weight loss, and anemia in association with a glucagon-secreting alpha-cell tumor of the pancreas. We present a 67-year-old diabetic patient with extensive cutaneous lesions, weight loss, and poor glycemic control. The clinical investigation revealed a pancreatic glucagonoma with resolution of the cutaneous and systemic features after surgical removal. The dermatologic and endocrine approach to this syndrome is discussed here. Early recognition and treatment may prevent metastatic disease and ensure its cure with resolution of the cutaneous and catabolic manifestations.
