Neurocysticercosis in Travelers: A Nation-Wide Study in Israel
Neurocysticercosis in Travelers: A Nation-Wide Study in Israel
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DOI：
10.1111/j.1708-8305.2011.00516.x
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发表时间：
2011-05-01
影响因子：
25.7
通讯作者：
Schwartz, Eli
中科院分区：
文献类型：
--
作者：
Leshem, Eyal;Kliers, Iris;Schwartz, Eli
方法：研究方法。我们对1994至2009年间以色列与旅行相关的NCC进行了一项全国范围的回顾性调查。在研究期间，以色列旅行者中诊断出9例NCC病例。大多数患者都去过南亚和/或东南亚。确诊时最常见的症状是癫痫。从可疑旅行返回到症状出现之间的平均间隔为3.2+/-1.8年。2例患者有多处皮损，其余为单发皮损，多数患者接受了抗寄生虫治疗，症状消失。使用阿苯达唑后，抗癫痫治疗的中位持续时间为16+/-41个月。停止抗癫痫治疗，无任何并发症。临床疾病的发病率估计为1：275,000次/次到流行地区。旅行者的NCC是一种罕见的现象，通常表现为旅行后数月至数年的癫痫发作障碍。抗寄生虫治疗后12至24个月的抗癫痫治疗导致我们的患者症状完全缓解。
Methods. We performed a retrospective, nation-wide survey of travel-related NCC in Israel between the years 1994 and 2009.Results. Nine cases of NCC were diagnosed in Israeli travelers during the study years. Most patients had traveled to South and/or Southeast Asia. The most common symptom at diagnosis was a seizure. The average interval between return from the suspected travel and symptom onset was 3.2 +/- 1.8 years. Two patients suffered from multiple lesions, whereas the rest had a single lesion.Antihelminthic treatment was given to most patients with resolution of symptoms. Median duration of antiepileptic treatment was 16 +/- 41 months after albendazole was given. Antiepileptic treatment was discontinued without any complications. The estimated attack rate of clinical disease was 1 : 275,000 per travel episode to an endemic region.Conclusions. NCC in travelers is a rare phenomenon commonly presenting as seizure disorder manifesting months to years post-travel. Antihelminthic therapy followed by 12 to 24 months of antiepileptic therapy resulted in complete resolution of symptoms in our patients.