Toxicological studies on silver nanoparticles: challenges and opportunities in assessment, monitoring and imaging.
Toxicological studies on silver nanoparticles: challenges and opportunities in assessment, monitoring and imaging.
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DOI：
10.2217/nnm.11.78
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发表时间：
2011-07
期刊：
影响因子：
--
通讯作者：
Sepúlveda MS
中科院分区：
文献类型：
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作者：
Stensberg MC;Wei Q;McLamore ES;Porterfield DM;Wei A;Sepúlveda MS
银纳米颗粒（Ag NPs）作为抗菌剂在消费品中越来越普遍。银NPs增强产品的使用增加可能导致环境银的毒性水平增加，但由于对银NPs的毒理学及其释放到环境中的速度的评估不足，对此类产品的使用或处置的监管控制滞后。在这篇文章中，我们结合传统的和最近建立的纳米颗粒表征方法，讨论了银纳米颗粒在细胞和有机体水平上的运输、活性和命运的最新研究。我们包括基于这些研究提出的几种细胞毒性机制，以及研究Ag NPs在生命系统中的摄取和命运的新机会。
Silver nanoparticles (Ag NPs) are becoming increasingly prevalent in consumer products as antibacterial agents. The increased use of Ag NP-enhanced products may lead to an increase in toxic levels of environmental silver, but regulatory control over the use or disposal of such products is lagging due to insufficient assessment on the toxicology of Ag NPs and their rate of release into the environment. In this article we discuss recent research on the transport, activity and fate of Ag NPs at the cellular and organismic level, in conjunction with traditional and recently established methods of nanoparticle characterization. We include several proposed mechanisms of cytotoxicity based on such studies, as well as new opportunities for investigating the uptake and fate of Ag NPs in living systems.