Genetic variance and lipolysis regulation: implications for obesity
Genetic variance and lipolysis regulation: implications for obesity
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遗传变异和脂肪分解调节：对肥胖的影响
DOI：
10.3109/07853890108995964
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发表时间：
2001
影响因子：
4.4
通讯作者：
P. Arner
中科院分区：
文献类型：
--
作者：
P. Arner
儿茶酚胺是人体脂肪细胞中主要的脂肪分解激素，肥胖症中描述了脂肪分解儿茶酚胺抵抗。对双胞胎和罕见遗传疾病的研究表明儿茶酚胺诱导的脂肪分解具有很强的遗传成分。儿茶酚胺受体信号通路的多态性已被描述，其中一些与肥胖有关。肾上腺素受体基因的许多多态性在转染的细胞系中具有功能。讨论了儿茶酚胺信号通路中多态性对脂肪分解调节的重要性。 β2 受体中的 Trp64Arg 多态性与肥胖相关，并伴随着人类脂肪细胞中受体脂解敏感性的变化。类似地，β2-肾上腺素受体中的 Gln 16Glu 和 Arg 16411e 变异导致人类脂肪细胞中该受体的脂解敏感性显着变化。此外，β2-肾上腺素受体基因多态性与肥胖相关。激素敏感脂肪酶基因中的二核苷酸（CA）内含子重复与肥胖有关，并显着降低儿茶酚胺激活脂肪酶的能力，从而降低人体脂肪细胞的脂肪分解能力。然而，β2-肾上腺素受体中的 Arg 389Gly 多态性会改变转染细胞系中的受体功能，但对人类脂肪细胞的脂肪分解没有影响，并且与肥胖无关。因此，参与儿茶酚胺信号转导的人类基因的多态性对脂肪细胞的脂肪分解有影响，也与肥胖有关。这些多态性的脂肪分解作用并不总能从人工细胞系的基因转移实验中预测出来。儿茶酚胺信号通路的遗传变异可能通过脂肪细胞脂肪分解的改变而促进肥胖。
Catecholamines are the major lipolytic hormones in human fat cells, and lipolytic catecholamine resistance is described in obesity. Studies on twins and in rare genetic disorders suggest a strong heredity component of catecholamine-induced lipolysis. Polymorphisms in catecholamine receptor signalling pathways have been described, several of which associate with obesity. Many polymorphisms in adrenoceptor genes are functional in transfected cell lines. The importance of polymorphisms in catecholamine signalling pathways for lipolysis regulation is discussed. A Trp64Arg polymorphism in the β2-receptor, which associates with obesity, is accompanied by changes in lipolytic sensitivity of the receptor in human fat cells. Similarly, a Gln 16Glu and an Arg 16411e variation in the β2-adrenoceptor cause marked variations in the lipolytic sensitivity of this receptor in human adipocytes. Furthermore, β2-adrenoceptor gene polymorphisms associate with obesity. A dinucleotide (CA) intron repeat in hormone-sensitive lipase gene is linked to obesity and markedly decreases the ability of catecholamines to activate the lipase and thereby lipolysis in human fat cells. However, an Arg 389Gly polymorphism in the β2-adrenoceptor, which alters receptor function in transfected cell lines, has no effect on lipolysis in human fat cells and is not associated with obesity. Thus, polymorphism in human genes that are involved in catecholamine signal transduction have effects on fat cell lipolysis and also relate to obesity. The lipolysis effects of these polymorphisms cannot always be predicted from gene transfer experiments on artificial cell lines. It is possible that genetic variance in catecholamine signalling pathways, through alterations in adipocyte lipolysis, may promote obesity.
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影响因子：
6.5
作者：
M. Lafontan;M. Berlan
通讯作者：
M. Lafontan;M. Berlan
DOI：
10.1073/pnas.97.19.10483
发表时间：
2000-09-12
影响因子：
11.1
作者：
Drysdale, CM;McGraw, DW;Liggett, SB
通讯作者：
Liggett, SB
第四跨膜结构域内的人 β2-肾上腺素能受体的多态性改变了受体的配体结合和功能特性。
DOI：
--
发表时间：
1993
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Green,SA;Cole,G;Jacinto,M;Innis,M;Liggett,SB
通讯作者：
Liggett,SB
钙和钙调蛋白在大鼠颌下腺释放激肽释放酶和色调剂中的作用。
DOI：
10.1152/ajpcell.1986.250.3.c480
发表时间：
1986
期刊：
The American journal of physiology
影响因子：
--
作者：
Maitra,SR;Carretero,OA;Smith,SW;Rabito,SF
通讯作者：
Rabito,SF