Alterations in working memory networks in amnestic mild cognitive impairment
Alterations in working memory networks in amnestic mild cognitive impairment
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DOI：
10.1080/13825585.2014.894958
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发表时间：
2015-01-02
影响因子：
1.9
通讯作者：
Morris, R. G.
中科院分区：
文献类型：
--
作者：
Migo, E. M.;Mitterschiffthaler, M.;Morris, R. G.
遗忘型轻度认知功能障碍（aMCI）患者的工作记忆保留或轻度受损，尽管他们的情节记忆缺陷。我们的目的是确定性能和/或aMCI患者和匹配的控制标准的工作记忆功能磁共振成像任务之间的神经差异。神经心理学评估显示，aMCI在言语和视觉情景长期记忆方面存在障碍，智商和执行功能完好无损。参与者完成了一个标准的三级N-back任务，其中患者未受损。对照组的功能激活出现在预期的区域，包括顶下小叶和背外侧前额叶皮层。组间差异被发现在舌回和舌回，并在一个区域的利益分析，在海马。在所有情况下，这些都是由于aMCI组中没有任务相关的失活引起的。结果与aMCI中任务相关失活失败的报告一致，可能是病理学的早期指征。
Patients with amnestic mild cognitive impairment (aMCI) show preserved or mildly impaired working memory, despite their deficits in episodic memory. We aimed to identify performance and/or neural differences between aMCI patients and matched controls on a standard working memory fMRI task. Neuropsychological assessment demonstrated aMCI impairments in verbal and visual episodic long-term memory, with intact IQ and executive function. Participants completed a standard three-level N-back task where patients were unimpaired. Functional activations in the control group were found in expected areas, including the inferior parietal lobule and dorsolateral prefrontal cortex. Group differences were found in the insula and lingual gyrus and, in a region of interest analysis, in the hippocampus. In all cases, these were caused by an absence of task-related deactivations in the aMCI group. The results are consistent with reports of failure in task-related deacivations in aMCI and could be early indications of pathology.