Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation.
Perfluoroaryl and Perfluoroheteroaryl Reagents as Emerging New Tools for Peptide Synthesis, Modification and Bioconjugation.
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DOI：
10.1002/chem.202103305
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发表时间：
2022-02-01
影响因子：
4.3
通讯作者：
Coxon, Christopher R.
中科院分区：
文献类型：
--
作者：
Brittain, William D. G.;Coxon, Christopher R.
肽和蛋白质作为药物、诊断试剂和生物医学科学的工具正变得越来越有价值。这在很大程度上是由操作和增强本地生物分子的新方法的出现所支撑的。全氟芳香族试剂可能是修饰多肽和蛋白质的最多样和最令人兴奋的工具之一，主要是因为它们的亲核取代化学、高电子缺陷以及它们的反应性能够调节到特定的亲核试剂。正如本文中所讨论的，近年来，全氟芳香族试剂在多肽合成中作为保护基团或活化基以及作为多肽修饰的正交柄得到了应用。此外，它们还应用于化学选择性的‘标记’、多肽和蛋白质的装订和生物结合，以及调节‘类药物’性质。本综述还将探讨这些试剂在生物化学中的应用前景。全氟芳香族和全氟杂芳烃试剂是近年来出现的多肽和蛋白质修饰的强效试剂。由于它们在温和的条件下具有区域和化学选择性的亲核取代化学，它们已被用于多肽合成、标记、环化、装订和蛋白质生物偶联。
Peptides and proteins are becoming increasingly valuable as medicines, diagnostic agents and as tools for biomedical sciences. Much of this has been underpinned by the emergence of new methods for the manipulation and augmentation of native biomolecules. Perfluoroaromatic reagents are perhaps one of the most diverse and exciting tools with which to modify peptides and proteins, due principally to their nucleophilic substitution chemistry, high electron deficiency and the ability for their reactivity to be tuned towards specific nucleophiles. As discussed in this minireview, in recent years, perfluoroaromatic reagents have found applications as protecting groups or activating groups in peptide synthesis and as orthogonal handles for peptide modification. Furthermore, they have applications in chemoselective ‘tagging’, stapling and bioconjugation of peptides and proteins, as well as tuning of ‘drug‐like’ properties. This review will also explore possible future applications of these reagents in biological chemistry. Perfluoroaromatic and perfluoroheteroaromatic reagents have emerged in recent years as powerful reagents for peptide and protein modification. Dominated by their regio‐ and chemoselective nucleophilic aromatic substitution chemistry under mild conditions, they have been used in peptide synthesis, tagging, cyclisation, stapling and protein bioconjugation.
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影响因子：
16.6
作者：
Embaby, Ahmed M.;Schoffelen, Sanne;Diness, Frederik
通讯作者：
Diness, Frederik
影响因子：
2.9
作者：
deGruyter JN;Malins LR;Baran PS
通讯作者：
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DOI：
10.1002/anie.201502607
发表时间：
2015-07-20
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
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作者：
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通讯作者：
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3.2
作者：
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通讯作者：
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影响因子：
4.6
作者：
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通讯作者：
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