Structure and properties of complexes of polycationic brushes with anionic liposomes
Structure and properties of complexes of polycationic brushes with anionic liposomes
复制标题
聚阳离子刷与阴离子脂质体复合物的结构和性能
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
A. Yaroslavov
中科院分区：
文献类型：
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作者：
O. V. Zaborova;A. Sybachin;M. Ballauff;A. Yaroslavov
研究了阴离子脂泡(脂质体)在含接枝聚阳离子链(阳离子刷)的胶体颗粒表面的吸附行为。脂质体刷剂在盐溶液中的稳定性随阴离子脂膜中阴离子脂含量的增加而增加；与含有20和30摩尔%阴离子脂类的脂质体在1.2MNaC l溶液中不解离成单独的组分。刷子结合的脂质体的完整性被保存下来。所开发的方法可用于获得生物活性化合物的纳米载体。
The adsorption of anionic lipid vesicles (liposomes) on the surfaces of colloidal particles containing grafted polycationic chains (cationic brushes) is studied. The stability of liposome-brush complexes in aqueous salt solutions increases with the content of anionic lipid in the liposomal membrane; complexes with liposomes containing 20 and 30 mol% anionic lipids do not dissociate into individual components in a 1.2 M NaCl solution. The integrity of the brush-bound liposomes is preserved. The developed approach can be used to obtain nanosized carriers for biologically active compounds.