Development of cholecystokinin binding sites in rat upper gastrointestinal tract.
Development of cholecystokinin binding sites in rat upper gastrointestinal tract.
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大鼠上胃肠道胆囊收缩素结合位点的发育。
DOI：
10.1152/ajpgi.1987.252.4.g529
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
McHugh,PR
中科院分区：
文献类型：
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作者：
Robinson,PH;Moran,TH;Goldrich,M;McHugh,PR
用~（125）I标记的博尔顿Hunter-CCK-33放射自显影法研究了大鼠上消化道不同发育阶段胆囊收缩素结合位点的分布。胆囊收缩素（CCK）结合存在于胎龄17天的大鼠胎儿的胃远端，食管和胃十二指肠连接处。在20天的胎儿中，在胃粘膜、胃窦环行肌和幽门括约肌中发现特异性结合。粘液结合在出生后发育过程中下降，并在第15天消失。胃窦结合在第10天和第15天急剧下降，到第50天消失。幽门肌结合存在于胎儿胃中，并持续在成人。在第10天之前未观察到胰腺CCK结合。提示CCK可能参与新生大鼠胃排空和摄食行为的调节。
Autoradiography using 125I-labeled Bolton Hunter-CCK-33 was used to study the distribution of cholecystokinin binding sites at different stages of development in the rat upper gastrointestinal tract. Cholecystokinin (CCK) binding was present in the distal stomach, esophagus, and gastroduodenal junction in the rat fetus of gestational age of 17 days. In the 20-day fetus, specific binding was found in the gastric mucosa, antral circular muscle, and pyloric sphincter. Mucosal binding declined during postnatal development and had disappeared by day 15. Antral binding declined sharply between day 10 and day 15 and disappeared by day 50. Pyloric muscle binding was present in fetal stomach and persisted in the adult. Pancreatic CCK binding was not observed before day 10. These results suggest that CCK may have a role in the control of gastric emptying and ingestive behavior in the neonatal rat.